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CIA-1 (Free base)

Name: CIA-1 (Free base)
Brand: TargetMol
SKU: T71534L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71534LCas No. 452087-38-6

Alias CIA-1(Free base)

CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhibits tumor growth in a mouse model of prostate cancer xenografts.

CIA-1 (Free base)

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Purity: 99%

Catalog No. T71534LAlias CIA-1(Free base)Cas No. 452087-38-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$238	In Stock	In Stock
50 mg	$371	In Stock	In Stock
100 mg	$572	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99%

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

CIA-1 (Free base) AI Summary

CIA-1 (Free base) exhibits bioactivity against luciferase/luciferin-expressing antifolate-resistant parasites infecting HepG2 cells. In the Luciferase Infection Assay, it shows an IC50 of 0.791 µM and an IC90 of 2.92 µM. The HepG2Tox Assay indicates a CC50 and CC90 of 0.791 µM. Additionally, in the Luciferase Expression Control, CIA-1 (Free base) has IC50 and IC90 values greater than 10.0 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhibits tumor growth in a mouse model of prostate cancer xenografts.
Synonyms	CIA-1(Free base)

Chemical Properties

Molecular Weight	329.42
Formula	C₁₇H₁₉N₃O₂S
Cas No.	452087-38-6
Smiles	N(CCC1=CC(OC)=C(OC)C=C1)C2=C3C(SC(C)=C3)=NC=N2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (182.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0356 mL	15.1782 mL	30.3564 mL	151.7819 mL
5 mM	0.6071 mL	3.0356 mL	6.0713 mL	30.3564 mL
10 mM	0.3036 mL	1.5178 mL	3.0356 mL	15.1782 mL
20 mM	0.1518 mL	0.7589 mL	1.5178 mL	7.5891 mL
50 mM	0.0607 mL	0.3036 mL	0.6071 mL	3.0356 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc