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IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Catalog No. TMPJ-00331
Synonyms: IFN-al, CRF2-1, IFN-alpha/beta receptor 1, human interferon-α receptor (HuIFN-α-Rec)10IFRC, α-type antiviral protein, AVP, Cytokine receptor family 2 member 1, IFN-alpha/beta R1, beta-type antiviral protein, IFN-α/β receptor 1, IFN-α/β R1, Cytokine receptor class-II member 1, β-type antiviral protein, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, alpha-type antiviral protein

Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

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IFNAR1 Protein, Rhesus macaque, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
Species Rhesus macaque
Expression System Human Cells
Tag C-6His
Accession Number A0A7N9D7J0
Synonyms IFN-al, CRF2-1, IFN-alpha/beta receptor 1, human interferon-α receptor (HuIFN-α-Rec)10IFRC, α-type antiviral protein, AVP, Cytokine receptor family 2 member 1, IFN-alpha/beta R1, beta-type antiviral protein, IFN-α/β receptor 1, IFN-α/β R1, Cytokine receptor class-II member 1, β-type antiviral protein, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, alpha-type antiviral protein
Amino Acid Ala25-Lys437
Construction Recombinant Rhesus Macaque Interferon Alpha/Beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala25-Lys437 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 70-120 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

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Keywords

IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al CRF2-1 b-type antiviral protein IFN-a/b R1 human interferon-a receptor (HuIFN-a-Rec)10IFRC IFN-alpha/beta receptor 1 human interferon-α receptor (HuIFN-α-Rec)10IFRC α-type antiviral protein AVP Cytokine receptor family 2 member 1 IFN-alpha/beta R1 beta-type antiviral protein IFN-α/β receptor 1 IFN-α/β R1 Cytokine receptor class-II member 1 IFN-a/b receptor 1 a-type antiviral protein β-type antiviral protein human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC alpha-type antiviral protein recombinant recombinant-proteins proteins protein

 

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