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Ethoxzolamide

Name: Ethoxzolamide
Brand: TargetMol
SKU: T5012
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5012Cas No. 452-35-7

Alias Redupresin, PNU-4191, L-643786

Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.

Ethoxzolamide

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Purity: 99.62%

Catalog No. T5012Alias Redupresin, PNU-4191, L-643786Cas No. 452-35-7

Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$44	In Stock
25 mg	$68	In Stock
50 mg	Inquiry	In Stock

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Batch Information

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Purity:99.62%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.
Targets&IC50	CA:1nM(Ki）
In vitro	Ethoxzolamide (ETZ) treatment leads to a greater than 90% reduction in reporter GFP fluorescence in infected macrophages and markedly impairs the intracellular growth of M. tuberculosis, as demonstrated in a 9-day macrophage survival assay.
Synonyms	Redupresin, PNU-4191, L-643786

Chemical Properties

Molecular Weight	258.32
Formula	C₉H₁₀N₂O₃S₂
Cas No.	452-35-7
Smiles	S(N)(=O)(=O)C=1SC=2C(N1)=CC=C(OCC)C2
Relative Density.	1.47g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (580.68 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8712 mL	19.3558 mL	38.7117 mL	193.5584 mL
5 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
10 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
20 mM	0.1936 mL	0.9678 mL	1.9356 mL	9.6779 mL
50 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL
100 mM	0.0387 mL	0.1936 mL	0.3871 mL	1.9356 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc