Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values under 0.3 nM [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values under 0.3 nM [1]. |
Targets&IC50 | PARP1:0.6 nM |
In vitro | PARP1-IN-14 (compound 19k) significantly inhibits the proliferation of drug-resistant Capan-1 cells (IC 50 < 0.3 nM) [1]. Treatment with PARP1-IN-14 (0-1 μM for 24 hours) induces DNA damage in both the parent Capan-1 (BRCA2 −/−) and the drug-resistant Capan-1 cells [1]. Additionally, PARP1-IN-14 (0-1 μM for 0-48 hours) triggers cell cycle arrest and apoptosis in both the parental and resistant cells [1]. |
Molecular Weight | 525.53 |
Formula | C28H24FN7O3 |
CAS No. | 2098639-70-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PARP1-IN-14 2098639-70-2 Chromatin/Epigenetic DNA Damage/DNA Repair PARP inhibitor inhibit