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HIV-1 TAT (48-60) Acetate
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Catalog No. T75964L
Alias HIV-1 TAT (48-60) Acetate(220408-24-2 Free base)
HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds.
HIV-1 TAT (48-60) Acetate
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Purity: 99.93%
Catalog No. T75964LAlias HIV-1 TAT (48-60) Acetate(220408-24-2 Free base)
HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $63 | - | In Stock | |
| 5 mg | $140 | - | In Stock | |
| 10 mg | $208 | - | In Stock | |
| 25 mg | $354 | - | In Stock | |
| 50 mg | $530 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds. |
| In vitro | Exogenous Tat proteins are able to activate the viral genome by penetrating the cell membrane and entering the nucleus.The HIV-1 TAT (48-60) Acetate peptide contains only the basic domain of the full-length peptide, but retains intact translocating activity, and at a standard dose of 1 mM is even more efficient at nuclear localization than other active peptides. [1] Cell-penetrating peptides are regarded as promising carriers for the delivery of large and hydrophilic molecules into cells. HIV-1 TAT (48-60) Acetate appeared to enter cells by endocytosis as observed by confocal laser scanning microscopy. [2] HIV-1 TAT (48-60) Acetate induces the formation of rod-like structures in DMPC, presumably inverted micelles, which may be intermediates as it crosses eukaryotic cell membranes. [3] |
| Synonyms | HIV-1 TAT (48-60) Acetate(220408-24-2 Free base) |
| Molecular Weight | 1779.07 |
| Formula | C72H135N35O18 |
| Smiles | O=C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O |
| Relative Density. | no data available |
| Sequence | Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln |
| Sequence Short | GRKKRRQRRRPPQ |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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