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Anti-ABCB1 Polyclonal Antibody
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Catalog No. TMAB-00021
Alias Phospholipid transporter ABCB1, PGY1, P-glycoprotein 1, Multidrug resistance protein 1, MDR1, CD243, ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, ABCB1
Anti-ABCB1 Polyclonal Antibody is a Rabbit antibody targeting ABCB1. Anti-ABCB1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
Anti-ABCB1 Polyclonal Antibody
Anti-ABCB1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00021Alias Phospholipid transporter ABCB1, PGY1, P-glycoprotein 1, Multidrug resistance protein 1, MDR1, CD243, ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, ABCB1
Anti-ABCB1 Polyclonal Antibody is a Rabbit antibody targeting ABCB1. Anti-ABCB1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ABCB1 Polyclonal Antibody is a Rabbit antibody targeting ABCB1. Anti-ABCB1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P. |
| Synonyms | Phospholipid transporter ABCB1, PGY1, P-glycoprotein 1, Multidrug resistance protein 1, MDR1, CD243, ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, ABCB1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Rat Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded Mouse Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 5. Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 6. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 7. Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 8. Paraformaldehyde-fixed, paraffin embedded Mouse Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MDR1 Polyclonal Antibody, Unconjugated (TMAB-00021) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.         |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in liver, kidney, small intestine and brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas. |
| Immunogen | KLH conjugated synthetic peptide: human MDR1 |
| Antigen Species | Human |
| Gene Name | ABCB1 |
| Gene ID | |
| Protein Name | ATP-dependent translocase ABCB1 |
| Uniprot ID | |
| Biology Area | P glycoproteins,ATPases,Channels,Side Population,Surface Molecules |
| Function | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Subunit : Interacts with PSMB5. |
| Molecular Weight | Theoretical: 141 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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