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PZ-1922 free base
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Catalog No. T209297Cas No. 1648745-65-6
PZ-1922 free base is a brain-penetrant 5-HT6R/5-HT3R antagonist with Ki values of 17 nM and 0.45 nM, respectively. It reversibly inhibits MAO-B (pIC50: 8.93). In rat novel object recognition (NOR) tests, PZ-1922 free base counteracts Scopolamine (SCOP)-induced memory deficits and prevents Aβ-induced memory decline in T-maze tests.
PZ-1922 free base
🥰Excellent
Catalog No. T209297Cas No. 1648745-65-6
PZ-1922 free base is a brain-penetrant 5-HT6R/5-HT3R antagonist with Ki values of 17 nM and 0.45 nM, respectively. It reversibly inhibits MAO-B (pIC50: 8.93). In rat novel object recognition (NOR) tests, PZ-1922 free base counteracts Scopolamine (SCOP)-induced memory deficits and prevents Aβ-induced memory decline in T-maze tests.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PZ-1922 free base is a brain-penetrant 5-HT6R/5-HT3R antagonist with Ki values of 17 nM and 0.45 nM, respectively. It reversibly inhibits MAO-B (pIC50: 8.93). In rat novel object recognition (NOR) tests, PZ-1922 free base counteracts Scopolamine (SCOP)-induced memory deficits and prevents Aβ-induced memory decline in T-maze tests. |
| Molecular Weight | 376.88 |
| Formula | C22H21ClN4 |
| Cas No. | 1648745-65-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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