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Orexin 2 Receptor Agonist

Name: Orexin 2 Receptor Agonist
Brand: TargetMol
SKU: T3177
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3177Cas No. 1796565-52-0

Alias OX2R

Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.

Orexin 2 Receptor Agonist

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Purity: 99.43%

Catalog No. T3177Alias OX2RCas No. 1796565-52-0

Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$245	In Stock	In Stock
100 mg	$358	In Stock	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Color:White

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Product Introduction

Orexin 2 Receptor Agonist AI Summary

Orexin 2 Receptor Agonist exhibits significant agonist activity on human orexin receptors, particularly OX2R, with an EC50 of 23.0 nM and a selectivity ratio of 70.0, compared to an EC50 of 1616.0 nM for OX1R in calcium mobilization assays. It shows a profile of displacing [125I]orexin-A from OX1R and OX2R with Ki values of 140.0 nM and 770.0 nM, respectively. Additionally, Orexin 2 Receptor Agonist displays bioactivity against SARS-CoV-2 by inhibiting the 3CL-Pro protease at 20 µM with an inhibition percentage of 22.12%, and it reduces SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM. These findings highlight its potential as a selective OX2R agonist with antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
Targets&IC50	OX2 recepter:23 nM(EC50)
Synonyms	OX2R

Chemical Properties

Molecular Weight	586.7
Formula	C₃₂H₃₄N₄O₅S
Cas No.	1796565-52-0
Smiles	S(NC1=CC(NCCNC(=O)C2=CC(C)=CC=C2)=CC=C1)(=O)(=O)C=3C=C(C=CC3OC)C4=CC(C(N(C)C)=O)=CC=C4
Relative Density.	1.275 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (85.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7044 mL	8.5222 mL	17.0445 mL	85.2224 mL
5 mM	0.3409 mL	1.7044 mL	3.4089 mL	17.0445 mL
10 mM	0.1704 mL	0.8522 mL	1.7044 mL	8.5222 mL
20 mM	0.0852 mL	0.4261 mL	0.8522 mL	4.2611 mL
50 mM	0.0341 mL	0.1704 mL	0.3409 mL	1.7044 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc