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Anti-IL-1RA Antibody (8J132) (Synonyms: interleukin 1 receptor antagonist)
Catalog No. TMAY-00305 Copy Product Info
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Anti-IL-1RA Antibody (8J132) is a Mouse antibody targeting IL-1RA. Anti-IL-1RA Antibody (8J132) can be used in ELISA.
Anti-IL-1RA Antibody (8J132)
Copy Product Info🥰Excellent
Catalog No. TMAY-00305
Synonyms interleukin 1 receptor antagonist
Anti-IL-1RA Antibody (8J132) is a Mouse antibody targeting IL-1RA. Anti-IL-1RA Antibody (8J132) can be used in ELISA.
Anti-IL-1RA Antibody
(8J132)
(8J132)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $199 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-IL-1RA Antibody (8J132) is a Mouse antibody targeting IL-1RA. Anti-IL-1RA Antibody (8J132) can be used in ELISA. |
| Synonyms | interleukin 1 receptor antagonist |
| Ig Type | Mouse IgG1 |
| Clone | 8J132 |
| Reactivity | Human |
| Specificity | Human IL-1RA/IL-1RN No cross-reactivity in ELISA with Human IL1RA Human IL1R4 Human SIGIRR Human IL1b Human IL1R2 Human IL1R1 Mouse IL1a Mouse IL1b E.coli cell lysate |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RA (rh IL-1RA; TMPY-00853; NP_776214.1; Arg 26-Glu 177). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein-encoding gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL1RA protein (TMPY-00853) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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