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Repotrectinib

Name: Repotrectinib
Brand: TargetMol
SKU: T4071
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4071Cas No. 1802220-02-5

Alias TPX-0005, TPX0005, TPX 0005

Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R.

Repotrectinib

🥰Excellent

Purity: 99.92%

Catalog No. T4071Alias TPX-0005, TPX0005, TPX 0005Cas No. 1802220-02-5

Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R.

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$289	In Stock
50 mg	$438	In Stock
100 mg	$658	In Stock
200 mg	$919	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Purity:99.92%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R.
Targets&IC50	Src:5.3 nM, ALK (L1196M):1.08 nM, ALK (WT):1.01 nM, ALK (G1202R):1.26 nM
Synonyms	TPX-0005, TPX0005, TPX 0005

Chemical Properties

Molecular Weight	355.37
Formula	C₁₈H₁₈FN₅O₂
Cas No.	1802220-02-5
Smiles	C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (168.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8140 mL	14.0698 mL	28.1397 mL	140.6984 mL
5 mM	0.5628 mL	2.8140 mL	5.6279 mL	28.1397 mL
10 mM	0.2814 mL	1.4070 mL	2.8140 mL	14.0698 mL
20 mM	0.1407 mL	0.7035 mL	1.4070 mL	7.0349 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL	2.8140 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc