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MBCQ

🥰Excellent
Catalog No. T21965Cas No. 150450-53-6

MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.

MBCQ

MBCQ

🥰Excellent
Purity: 99.45%
Catalog No. T21965Cas No. 150450-53-6
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$39In StockIn Stock
10 mg$73In StockIn Stock
25 mg$148In StockIn Stock
50 mg$245In StockIn Stock
100 mg$353In StockIn Stock
200 mg$492In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.45%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.
Targets&IC50
PDE5:19 nM (IC50), PDE2:>100 μM (IC50), PDE4:>100 μM (IC50), PDE1:>100 μM (IC50), PDE3:>100 μM (IC50)
In vitro
MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins[1].
Chemical Properties
Molecular Weight313.74
FormulaC16H12ClN3O2
Cas No.150450-53-6
SmilesClc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (79.68 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (6.37 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1874 mL15.9368 mL31.8735 mL159.3676 mL
5 mM0.6375 mL3.1874 mL6.3747 mL31.8735 mL
10 mM0.3187 mL1.5937 mL3.1874 mL15.9368 mL
20 mM0.1594 mL0.7968 mL1.5937 mL7.9684 mL
50 mM0.0637 mL0.3187 mL0.6375 mL3.1874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Phosphodiesterase (PDE)phosphodiesterasePGF2αPDE5MBCQInhibitorinhibitcoronarycGMP-PDEarteries
Related Tags: buy MBCQ | purchase MBCQ | MBCQ cost | order MBCQ | MBCQ chemical structure | MBCQ in vitro | MBCQ formula | MBCQ molecular weight
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