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Synonyms: SCTE, Klnc, KLK-L2, KLKL2, KLK5, Kallikrein c


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $90 | 7-10 days | 7-10 days | |
| 10 µg | $138 | 7-10 days | 7-10 days | |
| 20 µg | $215 | 7-10 days | 7-10 days | |
| 50 µg | $392 | 7-10 days | 7-10 days | |
| 100 µg | $619 | 7-10 days | 7-10 days | |
| 200 µg | $988 | 7-10 days | 7-10 days | |
| 500 µg | $1,830 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Cynomolgus Kallikrein 5, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Kallikrein 5 Antibody, hFc Tag with the EC50 of 5.0 ng/ml determined by ELISA (QC Test). |
| Description | Kallikrein 5/KLK5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 Cells. The accession number is XP_005590112.3. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | XP_005590112.3 |
| Construction | Ile65-Ser291 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 20 mM NaAc, 150 mM NaCl, 8% trehalose (pH 5.0). |
| Reconstitution | Reconstitute the lyophilized protein in 20 mM NaAC (pH 5.0). The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | SCTE, Klnc, KLK-L2, KLKL2, KLK5, Kallikrein c |
| Research Background | The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches. |
| Molecular Weight | 26.64 kDa (Predicted); 38-52 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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