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Anti-ERCC8 Antibody (1V748)
😃Good
Catalog No. TMAB-05660
Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP.
Anti-ERCC8 Antibody (1V748)
Anti-ERCC8 Antibody (1V748)
😃Good
Catalog No. TMAB-05660
Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ERCC8 Antibody (1V748) is a Rabbit antibody targeting ERCC8. Anti-ERCC8 Antibody (1V748) can be used in WB,IP. |
| Ig Type | IgG |
| Clone | 1V748 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. |
| Immunogen | A synthesized peptide: human ERCC8 |
| Antigen Species | Human |
| Gene Name | ERCC8 |
| Gene ID | |
| Protein Name | DNA excision repair protein ERCC-8 |
| Uniprot ID | |
| Function | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. |
| Molecular Weight | Theoretical: 44 kDa. Actual: 44 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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