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(+)-Ketoconazole

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Catalog No. T13464Cas No. 142128-59-4
Alias (+)-R41400, (+)-R 41400, (+)-Ketoconazol

(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.

(+)-Ketoconazole
Other Forms of (+)-Ketoconazole:

(+)-Ketoconazole

🥰Excellent
Purity: 99.79%
Catalog No. T13464Alias (+)-R41400, (+)-R 41400, (+)-KetoconazolCas No. 142128-59-4
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
10 mg$72In Stock
1 mL x 10 mM (in DMSO)$69In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
In vitro
(+)-Ketoconazole, an imidazole derivative, is a broad-spectrum systemic antifungal agent with oral activity that effectively inhibits CYP3A4 activity in human liver microsomes. [1]
In vivo
Perinatal exposure of female rats to (+)-Ketoconazole (3-6-12mg/kg.d), adolescence or adulthood (3-12-48mg/kg.d) showed that perinatal exposure to the highest dose of (+)-Ketoconazole delayed the maturation of GnRH secretion before puberty, while adolescent or adult exposure had no effect on GnRH pulsation. [2]
Synonyms(+)-R41400, (+)-R 41400, (+)-Ketoconazol
Chemical Properties
Molecular Weight531.43
FormulaC26H28Cl2N4O4
Cas No.142128-59-4
SmilesC([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (37.63 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8817 mL9.4086 mL18.8172 mL94.0858 mL
5 mM0.3763 mL1.8817 mL3.7634 mL18.8172 mL
10 mM0.1882 mL0.9409 mL1.8817 mL9.4086 mL
20 mM0.0941 mL0.4704 mL0.9409 mL4.7043 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

(+)Ketoconazole(+) Ketoconazole
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