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SU11652

Name: SU11652
Brand: TargetMol
SKU: T28874
Rating: 4.5 (1 reviews)

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Catalog No. T28874Cas No. 326914-10-7

Alias SU-11652, SU 11652

SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit. SU11652 disrupts the function of all forms of mutant Kit and may be used in the study of cancers involving Kit mutations.

SU11652

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Purity: 99.14%

Catalog No. T28874Alias SU-11652, SU 11652Cas No. 326914-10-7

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Purity:99.14%

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Product Introduction

Bioactivity

Description	SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit. SU11652 disrupts the function of all forms of mutant Kit and may be used in the study of cancers involving Kit mutations.
Targets&IC50	c-Kit:0.05 μM, FLK1:0.03 μM, PDGFR:0.01 μM
In vitro	SU11652 (0–1 μM, 0–72 hours) was used to treat mast cell lines expressing mutant Kit. SU11652 inhibited cell growth and induced cell cycle arrest followed by apoptosis [1].
Synonyms	SU-11652, SU 11652

Chemical Properties

Molecular Weight	414.93
Formula	C₂₂H₂₇ClN₄O₂
Cas No.	326914-10-7
Smiles	C(=C\1/C=2C(NC1=O)=CC=C(Cl)C2)\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3
Relative Density.	no data available
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (19.28 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4100 mL	12.0502 mL	24.1005 mL	120.5023 mL
5 mM	0.4820 mL	2.4100 mL	4.8201 mL	24.1005 mL
10 mM	0.2410 mL	1.2050 mL	2.4100 mL	12.0502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc