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6-Methoxyflavanone

Name: 6-Methoxyflavanone
Brand: TargetMol
SKU: TN3174
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN3174Cas No. 3034-04-6

Alias NSC50184

6-Methoxyflavanone (6-MeOF) is a positive allosteric modulator of the GABA response in human recombinant GABA A receptors, exhibiting antianxiety and anti-inflammatory properties, and is used to alleviate cisplatin-induced neuropathic pain.

6-Methoxyflavanone

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Purity: 99.86%

Catalog No. TN3174Alias NSC50184Cas No. 3034-04-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$40	-	In Stock
1 g	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

6-Methoxyflavanone AI Summary

6-Methoxyflavanone is a multi-target bioactive compound demonstrating a wide range of pharmacological activities. It increases EGR1 mRNA expression in human HEK293 cells at a concentration of 20 ug/mL after 6 to 12 hours, with a fold change (FC) of 1.6 as measured by dual-glo luciferase assay. In human MDA-kb2 cells, it exhibits antagonist activity at the androgen receptor, inhibiting DHT-induced luciferase activity with an IC50 value of 39500.0 nM, while also showing agonist activity at both the glucocorticoid and androgen receptors with EC150 values of 4077.0 uM. Additionally, 6-Methoxyflavanone inhibits BCRP and P-gp transporters, as well as MDR1, with IC50 values of 19000.0 nM for BCRP in MDCK cells, 46000.0 nM for BCRP in MCF-7 MX cells, 39000.0 nM for P-gp in A2780adr cells, and 64000.0 nM for MDR1 in MDCK cells. The compound also exhibits various other activities, including inhibition of JMJD2A-Tudor Domain, activation of Nrf2, inhibition of Marburg Virus entry, inhibition of Secretory Acid Sphingomyelinase (S-ASM), induction of DNA re-replication in colon adenocarcinoma cells, acting as a GLP-1 Receptor Inverse Agonist, activating gsp mutation linked to Fibrous Dysplasia/McCune-Albright Syndrome, inhibiting human TDP1 in the presence of CPT, and acting as an antagonist of EPAC2. This wide range of activities highlights its potential as a pharmacologically versatile compound..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	6-Methoxyflavanone (6-MeOF) is a positive allosteric modulator of the GABA response in human recombinant GABA A receptors, exhibiting antianxiety and anti-inflammatory properties, and is used to alleviate cisplatin-induced neuropathic pain.
Synonyms	NSC50184

Chemical Properties

Molecular Weight	254.28
Formula	C₁₆H₁₄O₃
Cas No.	3034-04-6
Smiles	COc1ccc2OC(CC(=O)c2c1)c1ccccc1
Relative Density.	1.199g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (58.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9327 mL	19.6634 mL	39.3267 mL	196.6336 mL
5 mM	0.7865 mL	3.9327 mL	7.8653 mL	39.3267 mL
10 mM	0.3933 mL	1.9663 mL	3.9327 mL	19.6634 mL
20 mM	0.1966 mL	0.9832 mL	1.9663 mL	9.8317 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9327 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc