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17-trifluoromethylphenyl trinor Prostaglandin F2α

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Catalog No. T37946Cas No. 221246-34-0
Alias 17-trifluoromethylphenyl trinor Prostaglandin F2α

17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma, with unsubstituted or meta-substituted aromatic derivatives being the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α, which contains an aromatic ring reminiscent of the trifluoromethyl-phenoxy ring in travoprost ((+)-fluprostenol isopropyl ester), is expected to act similarly to the free acid form of travoprost as an ocular hypotensive agent. Additionally, 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient with a potency equal to or greater than that of fluprostenol and cloprostenol.

17-trifluoromethylphenyl trinor Prostaglandin F2α

17-trifluoromethylphenyl trinor Prostaglandin F2α

😃Good
Catalog No. T37946Alias 17-trifluoromethylphenyl trinor Prostaglandin F2αCas No. 221246-34-0
17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma, with unsubstituted or meta-substituted aromatic derivatives being the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α, which contains an aromatic ring reminiscent of the trifluoromethyl-phenoxy ring in travoprost ((+)-fluprostenol isopropyl ester), is expected to act similarly to the free acid form of travoprost as an ocular hypotensive agent. Additionally, 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient with a potency equal to or greater than that of fluprostenol and cloprostenol.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$22335 days35 days
5 mg$97835 days35 days
10 mg$1,72035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma, with unsubstituted or meta-substituted aromatic derivatives being the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α, which contains an aromatic ring reminiscent of the trifluoromethyl-phenoxy ring in travoprost ((+)-fluprostenol isopropyl ester), is expected to act similarly to the free acid form of travoprost as an ocular hypotensive agent. Additionally, 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient with a potency equal to or greater than that of fluprostenol and cloprostenol.
Synonyms17-trifluoromethylphenyl trinor Prostaglandin F2α
Chemical Properties
Molecular Weight456.502
FormulaC24H31F3O5
Cas No.221246-34-0
SmilesO[C@@H](CCc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (54.76 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.19 mM), Sonication is recommended.
DMF: 30 mg/mL (65.72 mM), Sonication is recommended.
Ethanol: 50 mg/mL (109.53 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.1906 mL10.9529 mL21.9057 mL109.5285 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.4381 mL2.1906 mL4.3811 mL21.9057 mL
10 mM0.2191 mL1.0953 mL2.1906 mL10.9529 mL
20 mM0.1095 mL0.5476 mL1.0953 mL5.4764 mL
50 mM0.0438 mL0.2191 mL0.4381 mL2.1906 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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