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Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.70 nM.Camrelizumab exhibits anti-tumor activity and is well tolerated in the study cancers including NSC-LC, ESCC, Hodgkin's lymphoma and advanced HCC.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 575.00 | |
10 mg | Inquiry | $ 823.00 |
Description | Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.70 nM.Camrelizumab exhibits anti-tumor activity and is well tolerated in the study cancers including NSC-LC, ESCC, Hodgkin's lymphoma and advanced HCC. |
Targets&IC50 | PD-1/PD-L1:0.70 nM (IC50) |
In vitro | In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM.[2] |
In vivo | Camrelizumab (3 mg/kg) administered in combination with apatinib (200 and 100 mg/kg) demonstrated tumor inhibition rates of 63.1% and 87.3%, respectively, in human PD-1 transgenic mice.[1] |
Synonyms | SHR-1210 |
Molecular Weight | N/A |
CAS No. | 1798286-48-2 |
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store at -20°C
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Camrelizumab 1798286-48-2 SHR-1210 SHR 1210 SHR1210 inhibitor inhibit