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Camrelizumab (Synonyms: SHR-1210, Camrelizumab(anti-PD-1))
Catalog No. T37535 Copy Product Info
Purity: 98.6%
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Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC.
Camrelizumab
Copy Product Info🥰Excellent
Catalog No. T37535
Synonyms SHR-1210, Camrelizumab(anti-PD-1)
Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC.
Cas No. 1798286-48-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $163 | - | In Stock | |
| 5 mg | $575 | - | In Stock | |
| 10 mg | $823 | Inquiry | Inquiry | |
| 25 mg | $1,220 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.6%
Appearance:Liquid
Color:Transparent
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Chemical Properties
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| Description | Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC. |
| Targets&IC50 | PD-1/PD-L1:0.70 nM (IC50) |
| In vitro | In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM.[2] |
| In vivo | Camrelizumab (3 mg/kg) administered in combination with apatinib (200 and 100 mg/kg) demonstrated tumor inhibition rates of 63.1% and 87.3%, respectively, in human PD-1 transgenic mice.[1] |
| Synonyms | SHR-1210, Camrelizumab(anti-PD-1) |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDCD1/PD-1/CD279 |
| Molecular Weight | 143.69 kDa |
| Cas No. | 1798286-48-2 |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
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