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SDZ WAG 994

Name: SDZ WAG 994
Brand: TargetMol
SKU: T23347
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23347Cas No. 130714-47-5

SDZ WAG 994 is an A1 adenosine receptor agonist.

SDZ WAG 994

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🥰Excellent

Purity: 99.82%

Catalog No. T23347Cas No. 130714-47-5

SDZ WAG 994 is an A1 adenosine receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$185	In Stock	In Stock
25 mg	$333	In Stock	In Stock
50 mg	$479	In Stock	In Stock
100 mg	$653	In Stock	In Stock
200 mg	$879	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$129	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR CSFC

Product Introduction

SDZ WAG 994 AI Summary

SDZ WAG 994 displays a variety of bioactivities, demonstrating high affinity for adenosine A1 receptors (Ki = 76.0 nM) and moderate affinity for adenosine A2A receptors (Ki = 5700.0 nM). It inhibits isoprenaline-stimulated cAMP accumulation in vitro (IC50 = 40.0 nM) and exerts a negative inotropic effect on isolated guinea pig atria (EC50 = 18000.0 nM). In vivo, it reduces spontaneous locomotor activity (ED50 = 0.1 mg/kg) and inhibits DMCM-induced seizures (ED50 = 0.23 mg/kg) in mice, while also reducing hippocampal cell death in Mongolian gerbils after severe forebrain ischemia. Additionally, SDZ WAG 994 exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells (12.05% inhibition at 10 µM) and VERO-6 cells (0.05% inhibition at 10 µM), and inhibits the SARS-CoV-2 3CL-Pro protease (17.51% inhibition at 20 µM). It also demonstrates inhibitory activity towards human HDAC6, with inhibition rates of 13.2% and 8.24% using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

SDZ WAG 994 is an A1 adenosine receptor agonist.

Chemical Properties

Molecular Weight	363.41
Formula	C₁₇H₂₅N₅O₄
Cas No.	130714-47-5
Smiles	O(C)[C@H]1[C@H](N2C=3C(N=C2)=C(NC4CCCCC4)N=CN3)O[C@H](CO)[C@H]1O
Relative Density.	1.59g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1.1eq. NaOH: 36.34 mg/mL (100 mM), Sonication is recommended.

DMSO: 36 mg/mL (99.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO/1.1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	2.7517 mL	13.7586 mL	27.5171 mL	137.5856 mL
5 mM	0.5503 mL	2.7517 mL	5.5034 mL	27.5171 mL
10 mM	0.2752 mL	1.3759 mL	2.7517 mL	13.7586 mL
20 mM	0.1376 mL	0.6879 mL	1.3759 mL	6.8793 mL
50 mM	0.0550 mL	0.2752 mL	0.5503 mL	2.7517 mL

1.1eq. NaOH

	1mg	5mg	10mg	50mg
100 mM	0.0275 mL	0.1376 mL	0.2752 mL	1.3759 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc