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Fluvastatin sodium

Name: Fluvastatin sodium
Brand: TargetMol
SKU: T1487
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1487Cas No. 93957-55-2

Alias XU-62-320, XU 62320 sodium, Fluvastatin sodium salt

Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.

Fluvastatin sodium

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Purity: 99.56%

Catalog No. T1487Alias XU-62-320, XU 62320 sodium, Fluvastatin sodium saltCas No. 93957-55-2

Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$44	In Stock	In Stock
50 mg	$63	In Stock	In Stock
100 mg	$88	In Stock	In Stock
200 mg	$123	In Stock	In Stock
500 mg	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
Targets&IC50	HMG-CoA reductase:8 nM
In vitro	In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reversed the inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia.
In vivo	In human aortic smooth muscle cells, Fluvastatin (100 nM) reduces the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibits the formation of thiobarbituric acid-reactive substances in lipid peroxidation initiated by divalent iron ions (IC50=12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis.
Synonyms	XU-62-320, XU 62320 sodium, Fluvastatin sodium salt

Chemical Properties

Molecular Weight	433.45
Formula	C₂₄H₂₅FNNaO₄
Cas No.	93957-55-2
Smiles	[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10.8 mg/mL (24.92 mM), Sonication is recommended.

DMSO: 245 mg/mL (565.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3071 mL	11.5354 mL	23.0707 mL	115.3536 mL
5 mM	0.4614 mL	2.3071 mL	4.6141 mL	23.0707 mL
10 mM	0.2307 mL	1.1535 mL	2.3071 mL	11.5354 mL
20 mM	0.1154 mL	0.5768 mL	1.1535 mL	5.7677 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0461 mL	0.2307 mL	0.4614 mL	2.3071 mL
100 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc