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Targetmol provides additional products related to unsegmented cell signaling pathways for researchers in the life sciences and medicine fields, including inhibitors, agonists, modulators, degraders, and more.

TREM2 agonist-2
T627502738485-98-6In house
TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.
  • $283 TargetMol
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D-Luciferin potassium
T4139115144-35-9
D-Luciferin potassium (D-Luciferin K Salt) is a popular bioluminescent substrate of luciferase in the presence of ATP.
  • $41
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TargetMol | Inhibitor Hot
Iptacopan
T118641644670-37-0
Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM.
  • $132
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TargetMol | Inhibitor Hot
Lipopolysaccharides
T11855
Lipopolysaccharides (LPS) derived from Escherichia coli 055:B5, are a unique component of the cell wall of Gram-negative bacteria. They are composed of three regions: lipid A, oligosaccharide core, and O-specific polysaccharide (O-antigen). Lipopolysaccharides help maintain the integrity of the cell outer membrane and protect bacteria from damage by bile salts and lipid antibiotics. Lipopolysaccharides are highly immunogenic antigens that can enhance immune responses and can be used to construct inflammatory models.
  • $45
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
2-NBDG
T14017186689-07-6
2-NBDG is a fluorescent indicator for direct glucose uptake measurement. It is an indicator of cell viability.
  • $37
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TargetMol | Citations Cited
SBE-β-CD
T16858182410-00-0
SBE-β-CD (Sulfobutylether-β-Cyclodextrin) is a β-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether. SBE-β-CD is widely used as a co-solvent in biological experiments.
  • $41
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
PFB-FDGlu
T39518209540-62-5In house
PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity in living cells on an individual cell basis.
  • $152
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TargetMol | Inhibitor Hot
PEG300
T702225322-68-3
PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
  • $48
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TargetMol | Citations Cited
D18024
T10945110406-33-2In house
D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect.
  • $388
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TargetMol | Inhibitor Hot
Deoxynivalenol
T1509751481-10-8
Deoxynivalenol (Vomitoxin) is a mycotoxin produced by Fusarium spp. of the single trichothecene family and is commonly found in contaminated food and feed.Deoxynivalenol crosses the intestinal mucosa via a cellular bypass at the tight junctions.Deoxynivalenol transporters are unaffected by inhibitors of P-glycoprotein (PgP) or multidrug resistance-associated protein (MRP). Deoxynivalenol commonly causes diarrhea, vomiting, and gastrointestinal inflammation in humans and animals.
  • $147
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TargetMol | Inhibitor Hot
Evolocumab
T99201256937-27-5
Evolocumab is an inhibitor of the humanized monoclonal antibody PCSK9. It binds to circulating PCSK9 protein, resulting in inhibition of PCSK9 binding to LDLR. It can be used in studies of hypercholesterolemia and atherosclerotic cardiovascular disease.
  • $397
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
D-Lin-MC3-DMA
T58231224606-06-7
D-Lin-MC3-DMA, an ionizable cationic lipid, serves as a potent siRNA delivery vehicle.
  • $34
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TargetMol | Citations Cited
SM-102
T94102089251-47-6
SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.
  • $52
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TargetMol | Inhibitor Hot
Phos-tag Acrylamide AAL-107
T67772871839-54-2In house
Phos-tag Acrylamide AAL-107 is an acrylamide-pendant that can be used as a tool to visualize phosphorylated proteins.
  • $257
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TargetMol | Inhibitor Hot
Clozic
T1083922494-47-9In house
Clozic (ICI 55897) exhibits reversible anti-proliferative effects and can be used in studies about serving as a potential anti-arthritic agent.
  • $469
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TargetMol | Inhibitor Hot
5-A-RU hydrochloride
T10165L134452-11-2In house
5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) is an intermediate of bacterial riboflavin that activates mucosal-associated invariant T cells (MAIT).5-A-RU is used in the study of breast and prostate cancer.
  • $195
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TargetMol | Inhibitor Hot
BAY-524
T145051445830-39-6
BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
  • $93
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TargetMol | Inhibitor Hot
Magrolimab
T353902169232-81-7
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 IgG4 monoclonal antibody that exhibits antitumor activity by blocking CD47 and binding primarily to the N-terminal pyroglutamate of CD47. It can be used in combination with other compounds for the treatment of recurrent myeloma.
  • $189
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TargetMol | Inhibitor Hot
TargetMol
5-OP-RU
T853292408493-91-2In house
5-OP-RU is a MAIT-activating ligand, the major antigen of MAIT cells, a mucosal adjuvant, induces efficient enrichment of mucosal-associated invariant T cells, and can be used to study Mycobacterium tuberculosis infections.
  • $319
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Lucifer Yellow CH dipotassium
T7845471206-95-6In house
Lucifer Yellow CH dipotassium is a water-soluble fluorescent tracer that labels endocytosis vesicles in cells.Lucifer Yellow CH dipotassium excites and emits at a maximum wavelength of 430 nm and 540 nm, respectively.
  • $42
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TargetMol | Inhibitor Hot
Tezepelumab
T773591572943-04-4
Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor. Tezepelumab can be used to study advanced asthma disease.
  • $1,060
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AZD0780
T643622455427-91-3
AZD0780 (EX-A6975) is an oral small molecule PCSK9 inhibitor being developed by AstraZeneca as a first-in-class treatment for patients with dyslipidemia that is uncontrolled with statins alone.
  • $93
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TargetMol | Inhibitor Hot
FITC-Dextran (MW 4000)
T18988L
FITC-Dextran (MW 4000) is a marker composed of fluorescein isothiocyanate conjugated to 4 kDa dextran, widely used in microcirculation and cell permeability studies.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
OSMI-4
T123282260791-14-6In house
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.
  • $215
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TargetMol | Inhibitor Hot
1,1,1,1-Kestohexaose
T579062512-19-0
1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) is a natural product isolated from Poa ampla.
  • $76
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TargetMol | Inhibitor Hot
D-(-)-3-Phosphoglyceric acid disodium
T3718580731-10-8
D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) is an intermediate in glycolysis gluconeogenesis and the biosynthesis of serine, glycine, and threonine, competitively inhibiting yeast enolase. It also functions as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
  • $139
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TargetMol | Inhibitor Hot
Kainic acid
T15643487-79-6
In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes.
  • $98
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TargetMol | Inhibitor Hot
UDP-glucuronic acid trisodium
T1959563700-19-6
UDP-glucuronic acid trisodium (UDP-glucuronic acid trisodium) is an indispensable precursor for vital glycoconjugates in various biological domains. These glycoconjugates encompass mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids.
  • $32
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TargetMol | Inhibitor Hot
voxelotor
T75811446321-46-5
Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).
  • $33
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
BRD3067 FA
T30578L
BRD3067 FA is a structurally negative control for tubastatin A, which prevents it from entering the active site of the enzyme and protects neurons from H2O2.
  • $195
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Nitrocefin
T1970941906-86-9
Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.
  • $66
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Fucoxanthin
T76003351-86-8
Fucoxanthin (all-trans-Fucoxanthin) is a carotenoid naturally found in certain algae, serving as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, which imparts a brown or olive-green color. It exhibits anti-obesity, antioxidant, anti-diabetic, anticancer, and anti-inflammatory activities.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
(L)-Sodium lactate
T4103867-56-1
(L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
MV151
T68275945611-88-1In house
MV151 is a cell-permeable, fluorescent, broad-spectrum proteasome inhibitor that specifically targets all active subunits of the proteasome and immunoproteasome in living cells and can be used to label the proteasome in vitro and in vivo.
  • $1,450
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Biclotymol
T2680415686-33-6
Biclotymol is used in the study about infectious oropharyngeal diseases.
  • $350
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BLU0588
T601692810747-78-3In house
BLU0588 is a selective PRKACA inhibitor. BLU0588 inhibits PRKACA catalytic activity with a half-maximal inhibitory concentration (IC50) of 1 nM.
  • $195
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TargetMol | Inhibitor Hot
Tween 80
T139479005-65-6
Tween 80 is a nonionic surfactant and emulsifier that reduces bacterial adherence and inhibits biofilm formation. Tween 80 is widely used as a co-solvent in pharmacology experiments because of its ability to enhance the solubility of compounds in the aqueous phase.
  • $48
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
JBSNF-000028
T72947 In house
JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50s of 0.033 μM, 0.19 μM, and 0.21 μM, respectively.JBSNF-000028 can drive insulin sensitization and weight loss. 000028 drives insulin sensitization, glucose regulation and weight loss and can be used to study metabolic disorders.
  • $350
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TargetMol | Inhibitor Hot
Alexa fluor 647 NHS ester
T856221620475-28-6
Alexa fluor 647 NHS ester (L-5-Hydroxytryptophan-d3) is a photostable far-red fluorescent dye used in imaging and flow cytometry to generate stable signals for protein labeling, amine-modified oligonucleotides, and other primary amine-containing molecules.
  • $630
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TargetMol | Inhibitor Hot
Tribromoethyl alcohol
T080775-80-9
Tribromoethyl alcohol (Avertin) is an organic compound used to anesthetize mice.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Orellanine
T3381737338-80-0
Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat liver mitochondria.
  • $397
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TargetMol | Inhibitor Hot
Hellebrigenol
TN1729508-79-2
Hellebrigenol is a butadienolide extracted from the venom of the Vietnamese toad (Bufo vulgaris) with antitumor activity.
  • $166
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TargetMol | Inhibitor Hot
Phosal 50 PG
T19513774594-96-6
Phosal 50 PG is a co-solvent used as an emulsifier and stabilizer in the pharmaceutical and cosmetic industries.Phosal 50 PG is used as a dietary supplement.
  • $600
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TargetMol | Inhibitor Hot
Proteinase K
T893639450-01-6
Proteinase K (Protease K) is a non-specific serine protease that can tolerate changes in SDS, urea, pH (4-12), salt concentration, and temperature. Proteinase K hydrolyzes a wide range of peptide bonds and is used for protein digestion.
  • $97
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Cy5.5
TD0091
Cy5.5 is a near-infrared fluorescent dye for labeling biomolecules such as peptides, proteins and oligonucleotides (Ex=673 nm, Em=707 nm)[2].
  • $48
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Elamipretide
TP1095736992-21-5
Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. It is a potential therapeutic agent in the rare disease of Barnes syndrome.
  • $50
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Gadopentetic acid
T1933280529-93-7
Gadopentetic acid (gadolinium complex) (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies.
  • $41
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TargetMol | Inhibitor Hot
Human IgG1 kappa, Isotype Control
T78242
Human IgG1 kappa, Isotype Control is a humanized IgG-like monoclonal antibody and an isotype control antibody for human IgG1κ.
  • $247
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TargetMol | Inhibitor Hot