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BAN ORL 24 dihydrochloride

Name: BAN ORL 24 dihydrochloride
Brand: TargetMol
SKU: T10457
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10457Cas No. 1401463-54-4

BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.

BAN ORL 24 dihydrochloride

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Purity: 95.03%

Catalog No. T10457Cas No. 1401463-54-4

BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.03%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.
Targets&IC50	NOP receptor:50 μM, μ opioid receptor:0.224 μM
In vitro	BAN ORL 24 has antagonist for NOR (IC50=50 μM) and MOR (opioid receptor subtype) (IC50=0.224 μM). [1]
In vivo	BAN ORL 24 (10 mg/kg; i.v.) attenuated the duration of the thermal nociceptive antisensitization effect of BPRIM97 and inhibited BPRIM97-induced antinociceptive sensitization at 90 min postinjection. In tail-clip testing, BAN ORL 24 did not attenuate BPR1M97-induced antinociceptive sensitization at 30 min postinjection. [2]

Chemical Properties

Molecular Weight	506.51
Formula	C₂₇H₃₇Cl₂N₃O₂
Cas No.	1401463-54-4
Smiles	O=C([C@@H]1N(CCC1)CC2=CC=CC=C2)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (157.94 mM), Sonication is recommended.

DMSO: 180 mg/mL (355.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9743 mL	9.8715 mL	19.7429 mL	98.7147 mL
5 mM	0.3949 mL	1.9743 mL	3.9486 mL	19.7429 mL
10 mM	0.1974 mL	0.9871 mL	1.9743 mL	9.8715 mL
20 mM	0.0987 mL	0.4936 mL	0.9871 mL	4.9357 mL
50 mM	0.0395 mL	0.1974 mL	0.3949 mL	1.9743 mL
100 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.9871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc