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ML-792
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Catalog No. T16102Cas No. 1644342-14-2
ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor. ML-792 selectively inhibits SAE/SUMO1 and SAE/SUMO2 with IC50 of 3 and 11 nM.
ML-792
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Purity: 99.82%
Catalog No. T16102Cas No. 1644342-14-2
ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor. ML-792 selectively inhibits SAE/SUMO1 and SAE/SUMO2 with IC50 of 3 and 11 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | In Stock | In Stock | |
| 2 mg | $122 | In Stock | In Stock | |
| 5 mg | $197 | In Stock | In Stock | |
| 10 mg | $289 | In Stock | In Stock | |
| 25 mg | $455 | In Stock | In Stock | |
| 50 mg | $622 | In Stock | In Stock | |
| 100 mg | $888 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $249 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.82%
Appearance:Solid
Color:White
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Product Introduction
ML-792 AI Summary
ML-792 exhibits bioactivity by inhibiting the SUMO-activating enzyme (SAE) in both its recombinant form and human HCT116 cells, leading to a redistribution of SUMO2/3 proteins. It demonstrates cytotoxic effects on human HCT116 and OCI-LY10 cells, with EC50 values showing decreased cell viability. Additionally, the compound inhibits human CA1 and CA2 enzymes and interacts with human erythrocytes. Its pharmacokinetic properties include reasonable oral bioavailability, with distinct distribution and clearance rates in rat blood and plasma at varying doses..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor. ML-792 selectively inhibits SAE/SUMO1 and SAE/SUMO2 with IC50 of 3 and 11 nM. |
| Targets&IC50 | SAE/SUMO2:11 nM, SAE/SUMO1:3 nM |
| In vitro | METHODS: Cell lines (MDA-MB-468, HCT116,Colo-205, MDA-MB-231, A375) were treated with ML-792 (1 nM -10 μM) for 72 hours. Cell viability was determined using the CellTiter-Glo viability assay. RESULTS ML-792 showed a dose-dependent viability effect in all cell lines tested, with an EC50 value of 0.06 μM in MDA-MB-468 cells and 0.45 μM in A375 cells. [1] |
| Molecular Weight | 551.41 |
| Formula | C21H23BrN6O5S |
| Cas No. | 1644342-14-2 |
| Smiles | NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1ccn(Cc2cccc(Br)c2)n1 |
| Relative Density. | 1.74 g/cm3 (Predicted) |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 255 mg/mL (462.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.07 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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