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Anti-EMAP-II/AIMP1 Antibody (6N985)
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Catalog No. TMAY-01037
Alias SCYE1, p43, HLD3, EMAPII, EMAP-2, EMAP2
Anti-EMAP-II/AIMP1 Antibody (6N985) is a Mouse antibody targeting EMAP-II/AIMP1. Anti-EMAP-II/AIMP1 Antibody (6N985) can be used in IHC-P.
Anti-EMAP-II/AIMP1 Antibody (6N985)
Anti-EMAP-II/AIMP1 Antibody (6N985)
😃Good
Catalog No. TMAY-01037Alias SCYE1, p43, HLD3, EMAPII, EMAP-2, EMAP2
Anti-EMAP-II/AIMP1 Antibody (6N985) is a Mouse antibody targeting EMAP-II/AIMP1. Anti-EMAP-II/AIMP1 Antibody (6N985) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | SCYE1, p43, HLD3, EMAPII, EMAP-2, EMAP2 |
| Ig Type | Mouse IgG1 |
| Clone | 6N985 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human SCYE1 in human brain with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20-1:80 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AIMP1 / EMAP II (rh AIMP1 / EMAP II; TMPY-01461; NP_004748.2; Ala2-Lys312). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus protein which contains one tRNA-binding domain. AIMP1 (also known as p43) is a factor associated with a macromolecular aminoacyl-tRNA synthetase (ARS) complex but also plays diverse regulatory roles in various physiological processes. AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2. It suggests the novel activity of AIMP1 as a component of negative feedback loop of TGF-beta signaling. Recently, it been demonstrated that AIMP1 is also secreted and acts as a novel pleiotropic cytokine. AIMP1 protein induces the maturation and activation of DCs, which skew the immune response toward a Th1 response. AIMP1 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. AIMP1 is secreted from the pancreas upon glucose starvation, and it also plays a glucagon-like role in glucose homeostasis. Although AIMP1 was identified as a component of the macromolecular aminoacyl tRNA synthetase complex involved in the cellular translation process, it was also found to be secreted as a cytokine having complex physiological functions. Among these, AIMP1's angiostatic and immune stimulating activities suggest its potential use as a novel antitumor therapeutic protein. AIMP1 may exert its antitumor activity by inducing tumor-suppressing cytokines. Thus, AIMP1 may be useful as a novel anti-tumor agent. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human AIMP1 / EMAP II Protein (TMPY-01461) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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