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Mefloquine hydrochloride

Name: Mefloquine hydrochloride
Brand: TargetMol
SKU: T0860
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0860Cas No. 51773-92-3

Alias Mefloquine HCl, Mefloquin hydrochloride

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Mefloquine hydrochloride

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Purity: 99.99%

Catalog No. T0860Alias Mefloquine HCl, Mefloquin hydrochlorideCas No. 51773-92-3

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$54	In Stock	In Stock
200 mg	$72	In Stock	In Stock
500 mg	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Color:White

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COA HNMR LCMS

Product Introduction

Mefloquine hydrochloride AI Summary

Mefloquine hydrochloride exhibits a broad spectrum of bioactivities with significant antimalarial properties. It demonstrates potent inhibition of Plasmodium falciparum, including drug-resistant and sensitive strains, with low IC50 values in the nanomolar range, e.g., 2.372 nM for the resistant W2 strain. In various assays, it shows high levels of inhibition against the LDH activity of P. falciparum in erythrocytes, with compounds' XC50 values confirming its high potency. Moreover, the compound exhibits moderate inhibition of human HepG2 and Huh7 cell lines and possesses a moderate Inhibition Frequency Index (IFI), suggesting consistent activity across several platforms. Despite showing some level of cytotoxicity in assays involving Mycobacterium tuberculosis and Drosophila cells, Mefloquine hydrochloride also displayed inhibitory effects on bacterial pathogens such as Staphylococcus aureus MRSA (36.85%) and Acinetobacter baumannii (32.5%). Against other microbes, its activity was variable, such as 5.35% inhibition against Candida albicans and 18.63% against Pseudomonas aeruginosa. In in vivo studies, Mefloquine hydrochloride exhibited efficacy in a rodent model of Plasmodium berghei ANKA, significantly reducing blood parasite load at a dose of 9 mg/kg with rapid clearance times. The compound’s diverse inhibitory profile underscores its potential as a multifaceted therapeutic candidate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.
Targets&IC50	K+ channel:1 microM
Synonyms	Mefloquine HCl, Mefloquin hydrochloride

Chemical Properties

Molecular Weight	414.77
Formula	C₁₇H₁₇ClF₆N₂O
Cas No.	51773-92-3
Smiles	[C@@H](O)([C@@H]1NCCCC1)c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F.Cl
Relative Density.	1.383g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 76 mg/mL (183.23 mM), Sonication is recommended.

DMSO: 35.71 mg/mL (86.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.4110 mL	12.0549 mL	24.1097 mL	120.5487 mL
5 mM	0.4822 mL	2.4110 mL	4.8219 mL	24.1097 mL
10 mM	0.2411 mL	1.2055 mL	2.4110 mL	12.0549 mL
20 mM	0.1205 mL	0.6027 mL	1.2055 mL	6.0274 mL
50 mM	0.0482 mL	0.2411 mL	0.4822 mL	2.4110 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0241 mL	0.1205 mL	0.2411 mL	1.2055 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc