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Anti-RUVBL1 Antibody (1O231)
😃Good
Catalog No. TMAY-02688
Alias TIP49A, TIP49, TIH1, RVB1, RuvB-like AAA ATPase 1, Pontin52, PONTIN, NMP238, INO80H, ECP54
Anti-RUVBL1 Antibody (1O231) is a Mouse antibody targeting RUVBL1. Anti-RUVBL1 Antibody (1O231) can be used in IHC-P.
Anti-RUVBL1 Antibody (1O231)
Anti-RUVBL1 Antibody (1O231)
😃Good
Catalog No. TMAY-02688Alias TIP49A, TIP49, TIH1, RVB1, RuvB-like AAA ATPase 1, Pontin52, PONTIN, NMP238, INO80H, ECP54
Anti-RUVBL1 Antibody (1O231) is a Mouse antibody targeting RUVBL1. Anti-RUVBL1 Antibody (1O231) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RUVBL1 Antibody (1O231) is a Mouse antibody targeting RUVBL1. Anti-RUVBL1 Antibody (1O231) can be used in IHC-P. |
| Alias | TIP49A, TIP49, TIH1, RVB1, RuvB-like AAA ATPase 1, Pontin52, PONTIN, NMP238, INO80H, ECP54 |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 1O231 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human RUVBL1 in human colon carcinoma with mouse monoclonal antibody (1:100000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human RUVBL1 in human testis with mouse monoclonal antibody (1:100000, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20000-1:100000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RUVBL1 / RVB1 (rh RUVBL1 / RVB1; TMPY-03263; Q9Y265-1; Met1-Lys456). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. RUVBL1 is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. It also is essential for cell proliferation. RUVBL1 may be able to bind plasminogen at cell surface and enhance plasminogen activation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human RUVBL1 / RVB1 Protein (TMPY-03263) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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