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(1E,6E)-Bis(demethoxy)curcumin

🥰Excellent
Catalog No. T6S1688Cas No. 33171-05-0
Alias Didemethoxycurcumin, Curcumin III, BDMC

(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.

(1E,6E)-Bis(demethoxy)curcumin
Other Forms of (1E,6E)-Bis(demethoxy)curcumin:

(1E,6E)-Bis(demethoxy)curcumin

🥰Excellent
Purity: 97.45%
Catalog No. T6S1688Alias Didemethoxycurcumin, Curcumin III, BDMCCas No. 33171-05-0
(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.
Pack SizePriceAvailabilityQuantity
5 mg$37In Stock
10 mg$50In Stock
25 mg$78In Stock
50 mg$113In Stock
100 mg$163In Stock
200 mg$239In Stock
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Purity:97.45%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.
In vivo
Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids, that is, curcumin and demthoxycurcumin. BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells[1].
SynonymsDidemethoxycurcumin, Curcumin III, BDMC
Chemical Properties
Molecular Weight308.33
FormulaC19H16O4
Cas No.33171-05-0
SmilesC(=C/C(CC(/C=C/C1=CC=C(O)C=C1)=O)=O)\C2=CC=C(O)C=C2
Relative Density.1.285 g/cm3
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 31 mg/mL (100.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2433 mL16.2164 mL32.4328 mL162.1639 mL
5 mM0.6487 mL3.2433 mL6.4866 mL32.4328 mL
10 mM0.3243 mL1.6216 mL3.2433 mL16.2164 mL
20 mM0.1622 mL0.8108 mL1.6216 mL8.1082 mL
50 mM0.0649 mL0.3243 mL0.6487 mL3.2433 mL
100 mM0.0324 mL0.1622 mL0.3243 mL1.6216 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

InhibitorinhibitBisdemethoxycurcuminBis(demethoxy)curcuminAutophagyApoptosis(E,E)-Didemethoxycurcumin(E,E)-Curcumin III(E,E)-Bisdemethoxycurcumin
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