Carboxylesterase 2/CES2 Protein, Human, Recombinant (His)

Catalog No. TMPY-01776 Copy Product Info

Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1.

Carboxylesterase 2/CES2 Protein, Human, Recombinant (His)

Catalog No. TMPY-01776

Copy Product Info

Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$63	7-10 days	7-10 days
10 μg	$100	7-10 days	7-10 days
20 μg	$163	7-10 days	7-10 days
50 μg	$320	-	In Stock
100 μg	$567	7-10 days	7-10 days
200 μg	$1,000	7-10 days	7-10 days
500 μg	$2,120	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >20000 pmols/min/ug.
Description	Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	O00748-1
Synonyms	PCE-2,iCE,CES2A1,CE-2,carboxylesterase 2
Construction	A DNA sequence encoding the human CES2 isoform 1 (O00748-1) (Met 1-Leu 559) was expressed, with a C-terminal polyhistidine tag. Predicted N terminal: Gln 27
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	60.4 kDa (predicted); 60.4 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM NaAc, 150 mM NaCl, 10% Glycerol, pH 5. 5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.