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Phenazine-1-carboxylic acid

Name: Phenazine-1-carboxylic acid
Brand: TargetMol
SKU: TN7105
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7105Cas No. 2538-68-3

Phenazine-1-carboxylic acid shows strong antifungal activity against all phytopathogenic fungi, inhibiting the fungal growth by about 90-100%. Phenazine-1-carboxylic acid could be used to compete with other phytopathogenic fungi that attack grapevine

Phenazine-1-carboxylic acid

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Purity: 99.61%

Catalog No. TN7105Cas No. 2538-68-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$72	In Stock	In Stock
500 mg	$196	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Phenazine-1-carboxylic acid AI Summary

Phenazine-1-carboxylic acid exhibits a broad spectrum of bioactivities including antibacterial effects against Bacillus cereus (MIC < 0.5 µg/mL), Micrococcus luteus (MIC < 5.0 µg/mL), and Staphylococcus aureus (MIC < 5.0 µg/mL) observed through disk assay over 2 days. It also demonstrates antibacterial activity against methicillin-resistant Staphylococcus aureus, Mycobacterium fortuitum, Mycobacterium aurum, Mycobacterium vaccae, and Mycobacterium smegmatis with MIC values ranging from 25.0 to 100.0 µg/mL. Additionally, it inhibits Mycobacterium tuberculosis H37Rv ATCC 27292 with a MIC90 of 32.9 µg/mL, as determined using the Alamar blue assay. The compound displays substantial antifungal properties, inhibiting the mycelial growth of various fungal strains such as Botryosphaeria berengeriana, Fusarium spp., Mycosphaerella arachidis, Alternaria solani, and Colletotrichum falcatum, with EC50 values ranging from 3.58 to 18.5 µg/mL and an inhibition zone of 2.0 mm at 100 µg/disc after 10 to 15 days. Furthermore, Phenazine-1-carboxylic acid shows diverse bioactivities in multiple assays, including inhibition of ALDH1A1, influenza NS1 protein function, TGF-β, and inducing DNA re-replication in colon adenocarcinoma cells. However, it has no significant activity against human AChE, Bacillus subtilis DSM 347, or KIF5 cells, with IC50 values greater than 50000 nM. It also exhibits cytotoxicity against HCT116 cells with an IC50 value of 15600 nM after 5 days..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	224.21
Formula	C₁₃H₈N₂O₂
Cas No.	2538-68-3
Smiles	OC(=O)c1cccc2nc3ccccc3nc12
Relative Density.	No data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (22.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4601 mL	22.3005 mL	44.6010 mL	223.0052 mL
5 mM	0.8920 mL	4.4601 mL	8.9202 mL	44.6010 mL
10 mM	0.4460 mL	2.2301 mL	4.4601 mL	22.3005 mL
20 mM	0.2230 mL	1.1150 mL	2.2301 mL	11.1503 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc