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JAK1-IN-12
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Catalog No. T86756Cas No. 2945204-95-3
JAK1-IN-12, a selective inhibitor of JAK1, exhibits an IC50 of 0.0246 μM and demonstrates IC50 values of 0.423 μM, 0.410 μM, and 1.12 μM for JAK2, JAK3, and TYK2, respectively. It promotes hair growth in mice and is applicable for researching immune and inflammatory diseases [1].
JAK1-IN-12
😃Good
Catalog No. T86756Cas No. 2945204-95-3
JAK1-IN-12, a selective inhibitor of JAK1, exhibits an IC50 of 0.0246 μM and demonstrates IC50 values of 0.423 μM, 0.410 μM, and 1.12 μM for JAK2, JAK3, and TYK2, respectively. It promotes hair growth in mice and is applicable for researching immune and inflammatory diseases [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JAK1-IN-12, a selective inhibitor of JAK1, exhibits an IC50 of 0.0246 μM and demonstrates IC50 values of 0.423 μM, 0.410 μM, and 1.12 μM for JAK2, JAK3, and TYK2, respectively. It promotes hair growth in mice and is applicable for researching immune and inflammatory diseases [1]. |
| Targets&IC50 | JAK3:0.410 μM, JAK1:0.0246 μM, JAK2:0.423 μM, Tyk2:1.12 μM |
| In vitro | HDAC-IN-57 (Compound 12b) inhibits JAK1 and JAK2 in Ba/F3-TEL-JAK1 cell lines, with IC50 values of 0.110 μM and 6.105 μM, respectively [1]. At a concentration of 1 μM, HDAC-IN-57 (Compound 12b) exhibits strong interactions with JAK1, JAK3, PKD2, HPK1, and AurB in kinase panel assays [1]. |
| In vivo | JAK1-IN-12 (Compound 12b) was administered as a 2% solution in 10% DMSO, applied daily for one month, to 8-week-old C57/B6 mice to enhance hair growth in the shaved dorsal back region [1]. Animal Model: C57/B6 mice [1] Dosage: 2% in 10% DMSO solution Administration: Topical application; daily for 1 month Result: Induced skin darkening within 9 days and stimulated new hair growth within 13 days. |
| Molecular Weight | 349.43 |
| Formula | C20H23N5O |
| Cas No. | 2945204-95-3 |
| Smiles | N([C@@H]1[C@@]2(CC3(O)C[C@@]1(CC(C2)C3)[H])[H])C=4C(=CN=C5C4C=CN5)C=6C=NNC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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