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AKR1B10-IN-1

Catalog No. T39594 CAS 2136579-33-2

Synonyms: AKR1B10-IN-1

AKR1B10-IN-1, a powerful AKR1B10 (Aldo-Keto Reductase 1B10) inhibitor, demonstrates an IC50 value of 3.5 nM. This compound effectively curtails the proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.

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AKR1B10-IN-1, CAS 2136579-33-2

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 970.00

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Description	AKR1B10-IN-1, a powerful AKR1B10 (Aldo-Keto Reductase 1B10) inhibitor, demonstrates an IC50 value of 3.5 nM. This compound effectively curtails the proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.
Targets&IC50	AKR1B10:3.5 nM , AKR1B1:277 nM
In vitro	AKR1B10-IN-1 (compound 4e), at concentrations ranging from 0 to 20 μM over 96 hours, effectively inhibits the growth of both A549 and AKR1B10-stably overexpressing A549 cells (A549/1B10), demonstrating a potent ability to hinder cell proliferation attributed to both overexpressed and endogenous AKR1B10. Additionally, at concentrations up to 40 μM, with a 2-hour pre-treatment followed by a 24-hour incubation with cisplatin (CDDP), AKR1B10-IN-1 significantly reduces cell viability in cisplatin-resistant A549 cells (CDDP-R-A549) in a dose-responsive manner. Cell viability assays confirm these effects, showing a statistically significant suppression in A549 and A549/1B10 cell growth at 20 μM and a noticeable decrease in viability of CDDP-R-A549 cells, particularly at 40 μM, after pretreatment with AKR1B10-IN-1 followed by CDDP exposure.

Synonyms	AKR1B10-IN-1
Molecular Weight	341.338
Formula	C19H16FNO4
CAS No.	2136579-33-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Endo S, et al. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells [published correction appears in J Med Chem. 2018 Feb 8;61(3):1380]. J Med Chem. 2017;60(20):8441-8455.

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Keywords

AKR1B10-IN-1 2136579-33-2 AKR1B10 IN 1 AKR1B10IN1 AKR-1B10-IN-1 inhibitor inhibit

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