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Bococizumab
(Synonyms: RN316, PF-04950615) Copy Product Info
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Synonyms: RN316, PF-04950615
Catalog No. T76739 Copy Product Info
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Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to treat hypercholesterolemia.
Cas No. 1407495-02-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $347 | In Stock | In Stock | |
| 5 mg | $872 | In Stock | In Stock | |
| 10 mg | $1,390 | - | In Stock | |
| 25 mg | $1,980 | Inquiry | Inquiry | |
| 50 mg | $2,780 | Inquiry | Inquiry | |
| 100 mg | $3,750 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.9% (SDS-PAGE); 97.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to treat hypercholesterolemia. |
| In vivo | Bococizumab (0, 10, 30, and 100 mg/kg; i.v.; Pregnant Sprague-Dawley (SD) rats) decreases maternal and fetal cholesterol and shows good tolerance and no effects on ovarian or uterine parameters.[2] |
| Endotoxin | <1.0 EU/mg |
| Synonyms | RN316, PF-04950615 |
| Reactivity | Human |
| Verified Activity | Immobilized Human PCSK9 Protein (D374Y, His) (TMPY-04966) at 5 μg/mL can bind Bococizumab. The EC50 is 30.91 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PCSK9 |
| Molecular Weight | 145.0 kDa |
| Cas No. | 1407495-02-6 |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Bococizumab chemical structure | Bococizumab in vivo | Bococizumab molecular weight
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