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Bococizumab

Catalog No. T76739 CAS 1407495-02-6

Synonyms: RN316, PF-04950615

Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to treat hypercholesterolemia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bococizumab, CAS 1407495-02-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 347.00
5 mg	In stock	$ 872.00
10 mg	In stock	$ 1,390.00
25 mg	In stock	$ 1,980.00
50 mg	In stock	$ 2,780.00
100 mg	In stock	$ 3,750.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to treat hypercholesterolemia.
In vivo	Bococizumab (0, 10, 30, and 100 mg/kg; i.v.; Pregnant Sprague-Dawley (SD) rats) decreases maternal and fetal cholesterol and shows good tolerance and no effects on ovarian or uterine parameters.[2]

Synonyms	RN316, PF-04950615
Molecular Weight	N/A
CAS No.	1407495-02-6

Storage

store at low temperature

store at -20°C

References and Literature

1. Koutaro Yokote, et al. Efficacy and Safety of Bococizumab (RN316/PF-04950615), a Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, in Hypercholesterolemic Japanese Subjects Receiving a Stable Dose of Atorvastatin or Treatment-Naive - Results From a Randomized, Placebo-Controlled, Dose-Ranging Study. Circ J. 2017 Sep 25;81(10):1496-1505. 2. Sarah N Campion, et al. Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development. Regul Toxicol Pharmacol. 2015 Nov;73(2):562-70.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bococizumab 1407495-02-6 Others RN316 PF 04950615 RN-316 PF-04950615 PF04950615 RN 316 inhibitor inhibit

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