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C25-140

🥰Excellent
Catalog No. T7889Cas No. 1358099-18-9

C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.

C25-140

C25-140

🥰Excellent
Purity: 98.81%
Catalog No. T7889Cas No. 1358099-18-9
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$147In Stock
10 mg$198In Stock
25 mg$413In Stock
50 mg$679In Stock
100 mg$953In Stock
1 mL x 10 mM (in DMSO)$148In Stock
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Batch Information

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Purity:98.81%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
In vitro
C25-140 inhibits the interaction between TRAF6 and Ubc13 in a dose-dependent manner. At concentrations of 10-30 μM over 2 hours, it effectively reduces TRAF6-mediated ubiquitin chain formation.
Cell Research
Cell Line:TRAF6WT . Concentration:10 μM, 20 μM, 30 μM . Incubation Time:2 hours
Chemical Properties
Molecular Weight457.57
FormulaC26H31N7O
Cas No.1358099-18-9
SmilesCc1nn(c(C)c1CCC(=O)N1CCC(Cc2ccccc2)CC1)-c1ccc2nnc(C)n2n1
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 62.5 mg/mL (136.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1855 mL10.9273 mL21.8546 mL109.2729 mL
5 mM0.4371 mL2.1855 mL4.3709 mL21.8546 mL
10 mM0.2185 mL1.0927 mL2.1855 mL10.9273 mL
20 mM0.1093 mL0.5464 mL1.0927 mL5.4636 mL
50 mM0.0437 mL0.2185 mL0.4371 mL2.1855 mL
100 mM0.0219 mL0.1093 mL0.2185 mL1.0927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ubiquitin ligaseUbiquitin conjugating enzymeUbiquitin activating enzymeTumor Necrosis Factor ReceptorTRAF6-Ubc13TNFRTNF ReceptorNF-κBNFκBNF-kBNFkBInhibitorinhibitE3EnzymeE3 ligating enzymeE3 EnzymeE2EnzymeE2 EnzymeE2 conjugating enzymeE1EnzymeE1/E2/E3 EnzymeE1 EnzymeE1 activating enzymeC25-140C-25-140C25140C25 140
Related Tags: buy C25-140 | purchase C25-140 | C25-140 cost | order C25-140 | C25-140 chemical structure | C25-140 in vitro | C25-140 formula | C25-140 molecular weight
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