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Anti-AADAC Polyclonal Antibody
(Synonyms: DAC, CES5A1, Arylacetamide deacetylase(esterase), Arylacetamide deacetylase, Aadac, Aada, AAAD_HUMAN) Copy Product Info
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Synonyms: DAC, CES5A1, Arylacetamide deacetylase(esterase), Arylacetamide deacetylase, Aadac, Aada, AAAD_HUMAN
Catalog No. TMAB-02124 Copy Product Info
🥰Excellent
Anti-AADAC Polyclonal Antibody is a Rabbit antibody targeting AADAC. Anti-AADAC Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-AADAC Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-AADAC Polyclonal Antibody is a Rabbit antibody targeting AADAC. Anti-AADAC Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | DAC, CES5A1, Arylacetamide deacetylase(esterase), Arylacetamide deacetylase, Aadac, Aada, AAAD_HUMAN |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| Tissue Specificity | Mainly expressed in liver, small intestine, colon and adrenal gland. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth. |
| Immunogen | KLH conjugated synthetic peptide: human AADAC |
| Antigen Species | Human |
| Gene Name | AADAC |
| Gene ID | |
| Protein Name | Arylacetamide deacetylase |
| Uniprot ID | |
| Function | Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. |
| Molecular Weight | Theoretical: 46 kDa. Actual: 46 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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