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Anti-Prolactin Receptor Antibody-PE (8B416)
🥰Excellent
Catalog No. TMAY-00549P
Anti-Prolactin Receptor Antibody-PE (8B416) is a PE-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-PE (8B416) can be used in FCM.
Anti-Prolactin Receptor Antibody-PE (8B416)
Anti-Prolactin Receptor Antibody-PE (8B416)
🥰Excellent
Catalog No. TMAY-00549P
Anti-Prolactin Receptor Antibody-PE (8B416) is a PE-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-PE (8B416) can be used in FCM.
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Prolactin Receptor Antibody-PE (8B416) is a PE-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-PE (8B416) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8B416 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of human PRLR expression on MCF-7 cells. MCF-7 cells were stained with PE-conjugated anti-Human PRLR. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Prolactin Receptor / PRLR (rh Prolactin Receptor / PRLR; TMPY-01053; NP_000940.1; Met1-Asp234) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/HRP |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human Prolactin Receptor / PRLR protein (TMPY-01053) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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