Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2

Name: Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-05717U
Rating: 4.5 (1 reviews)

(Synonyms: Integrin α V β 8, Integrin alpha V β8) Copy Product Info

Synonyms: Integrin α V β 8, Integrin alpha V β8

Catalog No. TMPY-05717U Copy Product Info

Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P06756&P26012.

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
5 µg	$61	7-10 days	7-10 days
10 µg	$97	7-10 days	7-10 days
20 µg	$158	7-10 days	7-10 days
50 µg	$297	7-10 days	7-10 days
100 µg	$517	7-10 days	7-10 days
200 µg	$913	7-10 days	7-10 days
500 µg	$1,930	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P06756&P26012.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P06756&P26012
Construction	Phe31-Val992&Glu43-Arg684
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM NaCl, pH 8.0.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Integrin α V β 8, Integrin alpha V β8
Research Background	Integrin alpha V beta 8 is one of five alpha V integrins, is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization. Deletion of either alpha V or beta 8 reveals that alpha V beta 8 is required for vascular morphogenesis in the embryonic brain and yolk sac.

Chemical Properties

Molecular Weight

111.3 & 75.4 kDa (Predicted); 125-160 & 80-100 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Calculator

Reconstitution Calculator
Recombinant Protein Dilution Calculator
Specific Activity Calculator

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Recombinant Proteins

Keywords

TMPY-05717

Related Tags: Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2 chemical structure | Integrin alpha V beta 8 Protein, Human, Recombinant (His) V2 molecular weight