Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GnRH-R antagonist 1 (Compound 21a), is an orally active, membrane-permeable agent with a high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic efficacy (IC50=2.18 nM). It is utilized in research focused on advanced prostate cancer and the prevention of premature LH surges [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,420.00 | |
50 mg | 10-14 weeks | $ 3,180.00 | |
100 mg | 10-14 weeks | $ 4,300.00 |
Description | GnRH-R antagonist 1 (Compound 21a), is an orally active, membrane-permeable agent with a high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic efficacy (IC50=2.18 nM). It is utilized in research focused on advanced prostate cancer and the prevention of premature LH surges [1]. |
In vitro | GnRH-R antagonist 1 demonstrates a cell permeability that is 140 times greater than that of Relugolix, while also showing favorable stability in both human and mouse microsomes [1]. |
In vivo | GnRH-R antagonist 1 administered orally at a dosage of 30 mg/kg once daily for seven days exhibits a good safety profile [1]. At a single oral dose of 12 mg/kg, it demonstrates favorable pharmacokinetics and high oral bioavailability, evident from a 44.7% F% value [1]. Furthermore, this dosage effectively suppresses circulating testosterone levels in rats for over 24 hours [1]. |
Molecular Weight | 721.65 |
Formula | C31H28F5N7O6S |
CAS No. | 2826273-90-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GnRH-R antagonist 1 2826273-90-7 GPCR/G Protein GNRH Receptor inhibitor inhibit