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Tabituximab

(Synonyms: OTSA101, OTSA 101, ONC-005, ONC005) Copy Product Info
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Synonyms: OTSA101, OTSA 101, ONC-005, ONC005

Catalog No. T77449 Copy Product Info
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Tabituximab (ONC-005) is a humanized monoclonal antibody that targets FZD10 (FZD10), a Wnt receptor, and exhibits antitumor activity. Tabituximab binds to FZD10 on the surface of tumor cells, blocking the binding of Wnt ligands to the receptor, thereby inducing tumor cell apoptosis and inhibiting tumor invasion and metastasis. Tabituximab can be used in research on tumors and immune system diseases.
Tabituximab
Cas No. 1644134-10-0
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$360-In Stock
5 mg$1,120-In Stock
10 mg$1,770-In Stock
25 mg$3,360-In Stock
50 mgPreferential-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:98.7% (SDS-PAGE); 96.4% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Tabituximab (ONC-005) is a humanized monoclonal antibody that targets FZD10 (FZD10), a Wnt receptor, and exhibits antitumor activity. Tabituximab binds to FZD10 on the surface of tumor cells, blocking the binding of Wnt ligands to the receptor, thereby inducing tumor cell apoptosis and inhibiting tumor invasion and metastasis. Tabituximab can be used in research on tumors and immune system diseases.
In vitro
The non-radiolabeled Tabituximab antibody showed only weak inhibition of synovial sarcoma cell growth. [1]
In vivo
Yttrium-90 radiolabeled Tabituximab demonstrated significant anti-tumor effects after a single intravenous injection in a mouse xenograft model. [1]
SynonymsOTSA101, OTSA 101, ONC-005, ONC005
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetFZD10
Chemical Properties
Molecular Weight144.63 kDa
Cas No.1644134-10-0
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
StorageStore at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Keywords

Related Tags: Tabituximab chemical structure | Tabituximab in vivo | Tabituximab in vitro | Tabituximab molecular weight