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Synonyms: OTSA101, OTSA 101, ONC-005, ONC005


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $360 | - | In Stock | |
| 5 mg | $1,120 | - | In Stock | |
| 10 mg | $1,770 | - | In Stock | |
| 25 mg | $3,360 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
| Description | Tabituximab (ONC-005) is a humanized monoclonal antibody that targets FZD10 (FZD10), a Wnt receptor, and exhibits antitumor activity. Tabituximab binds to FZD10 on the surface of tumor cells, blocking the binding of Wnt ligands to the receptor, thereby inducing tumor cell apoptosis and inhibiting tumor invasion and metastasis. Tabituximab can be used in research on tumors and immune system diseases. |
| In vitro | The non-radiolabeled Tabituximab antibody showed only weak inhibition of synovial sarcoma cell growth. [1] |
| In vivo | Yttrium-90 radiolabeled Tabituximab demonstrated significant anti-tumor effects after a single intravenous injection in a mouse xenograft model. [1] |
| Synonyms | OTSA101, OTSA 101, ONC-005, ONC005 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | FZD10 |
| Molecular Weight | 144.63 kDa |
| Cas No. | 1644134-10-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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