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CE-224535

Name: CE-224535
Brand: TargetMol
SKU: T14920
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14920Cas No. 724424-43-5

Alias PF-04905428

CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.

CE-224535

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Purity: 99.68%

Catalog No. T14920Alias PF-04905428Cas No. 724424-43-5

CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$419	In Stock	In Stock
25 mg	$679	In Stock	In Stock
50 mg	$953	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock
200 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$247	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
In vitro	CE-224535 reduces leukocyte secretion of IL-1 and IL-18, thereby providing a novel therapeutic approach for the treatment of rheumatoid arthritis[1].
In vivo	In rats, CE-224535 exhibits a low CLp (11 mL/min/kg) and a large Vdss (7.6 L/kg), resulting in a half-life of 2.4 hours. Oral administration of CE-224535 (5 mg/kg) produces Cmax levels approximately 90 times higher than its IC90 in human blood (0.21 μg/mL or 0.44 μM)[2].
Synonyms	PF-04905428

Chemical Properties

Molecular Weight	480.94
Formula	C₂₂H₂₉ClN₄O₆
Cas No.	724424-43-5
Smiles	COC[C@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O
Relative Density.	1.47g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (197.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (20.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0793 mL	10.3963 mL	20.7926 mL	103.9631 mL
5 mM	0.4159 mL	2.0793 mL	4.1585 mL	20.7926 mL
10 mM	0.2079 mL	1.0396 mL	2.0793 mL	10.3963 mL
20 mM	0.1040 mL	0.5198 mL	1.0396 mL	5.1982 mL
50 mM	0.0416 mL	0.2079 mL	0.4159 mL	2.0793 mL
100 mM	0.0208 mL	0.1040 mL	0.2079 mL	1.0396 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc