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PKA

protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase . Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

  • Bucladesine sodium
    T141816980-89-5
    Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.
    • $31
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  • Capivasertib
    T19201143532-39-1
    Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.
    • $34
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  • Staurosporine
    T668062996-74-1
    Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6 15 2 3 3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
    • $56
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  • PKG Substrate acetate(81187-14-6 free base)
    TP1787L
    PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
    • $101
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  • A-674563 2HCl(552325-73-2(fb-2hcl))
    T6139L
    A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
    • $78
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  • JAK1/2/3 Inhibitor 1
    T7750416234-14-3
    JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the cancer cell backbone and inhibiting the production of new proteins.
    • $50
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  • Exisulind
    T2405159973-80-7
    Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
    • $47
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  • A-674563 HCl (552325-73-2(free base))
    T44442070009-66-2
    A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16 46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in th
    • $77
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  • Fasudil
    T1606103745-39-7
    Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
    • $33
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  • PKG inhibitor peptide TFA (82801-73-8 free base)
    TP1523
    PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).
    • $50
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  • CREBtide acetate(149155-45-3 free base)
    TP1876L
    CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
    • $75
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  • Gardenin A
    TN411421187-73-5
    Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
    • $197
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  • PKI (5-24) Acetate(99534-03-9 free base)
    TP1957L
    PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
    • $132
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  • AP-C2
    T77570682793-07-3
    AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.
    • $57
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  • HA-1004 dihydrochloride
    T868192564-34-6
    HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
    • $370
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  • PKA inhibitor fragment (6-22) amide Acetate
    T21674L
    PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).
    • $87
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  • Malantide acetate(86555-35-3 free base)
    TP1789L
    Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activity in vitro.
    • $78
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  • PKI 14-22 amide, myristoylated Acetate
    T21983L
    PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.
    • $298
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  • 8-Bromo-cGMP sodium
    T1406451116-01-9In house
    8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.
    • $55
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  • HA-1004
    T2752591742-10-8In house
    HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.
    • $195
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  • Ipatasertib dihydrochloride
    T153741396257-94-5In house
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively).
    • $39
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  • LX7101
    T157981192189-69-7In house
    LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
    • $56
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  • R547
    T6312741713-40-6In house
    R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1 2 4 with Ki of 2 nM 3 nM 1 nM. It is less potent to CDK7 and GSK3α β, while inactive to other kinases. Phase 1.
    • $45
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  • 8-Bromo-cAMP sodium salt
    T674776939-46-3
    8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase(PKA), but resistant to degradation by cyclic AMP phosphodiesterase.
    • $41
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  • Bilobetin
    T4S2128521-32-4
    Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
    • $39
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  • ML-7 hydrochloride
    T3050110448-33-4
    ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.
    • $30
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  • Fasudil hydrochloride
    T3060105628-07-7
    Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
    • $35
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  • MLN8054
    T6315869363-13-3
    MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
    • $48
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  • H-89 dihydrochloride
    T6250130964-39-5
    H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).
    • $33
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  • Ellagic acid
    T0465476-66-4
    Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
    • $44
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  • Ro-3306
    T2356872573-93-8
    RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
    • $32
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  • HA-100
    T764884468-24-6
    HA-100 is an inhibitor of protein kinase
    • $57
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  • Rottlerin
    T1679182-08-6
    Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
    • $35
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  • Piceatannol
    T061010083-24-6
    Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
    • $39
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  • PKItide
    T81447126370-52-3
    PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].
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  • KT5720
    T15669108068-98-0
    KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).
    • $198
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  • LX-7101 hydrochloride
    T329851374644-80-0
    LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
    • $195
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  • Protein kinase G inhibitor-1
    T67755354544-70-0
    Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.
    • $195
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  • Warangalone
    TQ00724449-55-2
    Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively.
    • $1,758
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  • α-Amyrin palmitate
    TN338322255-10-3
    alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki=6 microM), it also shows weak cytotoxicity against the A2780 human ovarian cancer cell line.
    • $280
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  • Cycloheterophyllin
    TN154236545-53-6
    Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.
    • $660
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  • Aplithianines A
    T82984
    Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by competitively interacting with the ATP pocket [1].
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  • KT5823
    T15670126643-37-6
    KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion uptake by modulating sodium iodide symporter protein expression and activity in thyroid cells. KT5823 induces apoptosis.
    • $3,200
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  • Isopedicin
    TN43174431-42-9
    Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.
    • $659
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  • Gliotoxin
    TN169467-99-2
    Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
    • $143
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  • Kemptide
    TP135165189-71-1
    Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
    • $110
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  • H-8 hydrochloride
    T22832113276-94-1
    H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.
    • $48
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  • BX-912
    T1837702674-56-4
    BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC etc.
    • $48
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  • A-674563
    T6139552325-73-2
    A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
    • $47
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  • Daphnetin
    T2851486-35-1
    Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.
    • $43
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