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Tonabersat
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Catalog No. T17116Cas No. 175013-84-0
Alias USL-260, USL260, SB-220453, SB220453
Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that regulates cellular communication between trigeminal ganglion neuronal cells and glial cells and inhibits neurogenic inflammation for the treatment of migraine and epilepsy.
Tonabersat
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Purity: 99.49%
Catalog No. T17116Alias USL-260, USL260, SB-220453, SB220453Cas No. 175013-84-0
Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that regulates cellular communication between trigeminal ganglion neuronal cells and glial cells and inhibits neurogenic inflammation for the treatment of migraine and epilepsy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | 7-10 days | |
| 5 mg | $225 | In Stock | |
| 10 mg | $378 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that regulates cellular communication between trigeminal ganglion neuronal cells and glial cells and inhibits neurogenic inflammation for the treatment of migraine and epilepsy. |
| In vitro | Tonabersat is a novel benzopyran derivative that blocks cortical spreading depression, which is thought to be involved in migraine attacks.[1] |
| In vivo | Methods: Fourteen days after inoculation with MDA231-BrM2 cells, mice were treated with Tonabersat (10 mg/kg), Meclofenamic Acid (10 mg/kg), and Carboplatin. Brain metastatic lesions were quantified by BLI following the indicated regimens. Results: Treatment with either Tonabersat or Meclofenamic Acid as a single agent significantly inhibited the progression of metastatic lesions. The addition of Carboplatin to either agent significantly inhibited brain metastasis. [2] |
| Alias | USL-260, USL260, SB-220453, SB220453 |
| Molecular Weight | 391.82 |
| Formula | C20H19ClFNO4 |
| Cas No. | 175013-84-0 |
| Smiles | N(C(=O)C1=CC(Cl)=C(F)C=C1)[C@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(C(C)=O)C3 |
| Relative Density. | 1.38g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (204.18 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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