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Tonabersat

Name: Tonabersat
Brand: TargetMol
SKU: T17116
Rating: 4.5 (1 reviews)

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Catalog No. T17116Cas No. 175013-84-0

Alias USL-260, USL260, SB-220453, SB220453

Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that regulates cellular communication between trigeminal ganglion neuronal cells and glial cells and inhibits neurogenic inflammation for the treatment of migraine and epilepsy.

Tonabersat

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Purity: 99.49%

Catalog No. T17116Alias USL-260, USL260, SB-220453, SB220453Cas No. 175013-84-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$99	7-10 days	7-10 days
5 mg	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.49%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that regulates cellular communication between trigeminal ganglion neuronal cells and glial cells and inhibits neurogenic inflammation for the treatment of migraine and epilepsy.
In vitro	Tonabersat is a novel benzopyran derivative that blocks cortical spreading depression, which is thought to be involved in migraine attacks.[1]
In vivo	Methods: Fourteen days after inoculation with MDA231-BrM2 cells, mice were treated with Tonabersat (10 mg/kg), Meclofenamic Acid (10 mg/kg), and Carboplatin. Brain metastatic lesions were quantified by BLI following the indicated regimens. Results: Treatment with either Tonabersat or Meclofenamic Acid as a single agent significantly inhibited the progression of metastatic lesions. The addition of Carboplatin to either agent significantly inhibited brain metastasis. [2]
Synonyms	USL-260, USL260, SB-220453, SB220453

Chemical Properties

Molecular Weight	391.82
Formula	C₂₀H₁₉ClFNO₄
Cas No.	175013-84-0
Smiles	N(C(=O)C1=CC(Cl)=C(F)C=C1)[C@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(C(C)=O)C3
Relative Density.	1.38g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (204.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5522 mL	12.7610 mL	25.5219 mL	127.6096 mL
5 mM	0.5104 mL	2.5522 mL	5.1044 mL	25.5219 mL
10 mM	0.2552 mL	1.2761 mL	2.5522 mL	12.7610 mL
20 mM	0.1276 mL	0.6380 mL	1.2761 mL	6.3805 mL
50 mM	0.0510 mL	0.2552 mL	0.5104 mL	2.5522 mL
100 mM	0.0255 mL	0.1276 mL	0.2552 mL	1.2761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc