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Anti-Bikunin/AMBP Antibody (9R49)

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Catalog No. TMAY-02499
Alias α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M

Anti-Bikunin/AMBP Antibody (9R49) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (9R49) can be used in IHC-P.

Anti-Bikunin/AMBP Antibody (9R49)

Anti-Bikunin/AMBP Antibody (9R49)

😃Good
Catalog No. TMAY-02499Alias α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M
Anti-Bikunin/AMBP Antibody (9R49) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (9R49) can be used in IHC-P.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Bikunin/AMBP Antibody (9R49) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (9R49) can be used in IHC-P.
Aliasα-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M
Ig Type
Monoclonal Mouse IgG1
Clone
9R49
Reactivity
Human
Verified Activity
Immunochemical staining of human A1pha-1-microglobulin in human liver with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections.
Application
IHC-P
Recommended Dose
IHC-P: 1:30-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Protein HC/Bikunin (rh Protein HC/Bikunin; TMPY-03044; NP_001624.1; Met1-Val203). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kunitz-type domain. Although previously believed to be constitutively expressed exclusively in liver, the present study demonstrates the induction of this gene by oxalate in porcine proximal tubular LLC-PK1 cells and rat kidney. In liver, the precursor protein is cleaved in the Golgi network by a furin-like enzyme to release constituent proteins, which undergo glycosylation before their export from the cell. In the renal tubular cells, A1M and bikunin co-precipitate, indicating lack of cleavage of the precursor protein. As the expression of the AMBP gene is regulated by A1M-specific cis elements and transcription factors, A1M protein was studied as a representative of AMBP gene expression in renal cells. The alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle, nervous system microvasculature, and connective tissue
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Protein HC/Bikunin Protein (TMPY-03044)
Antigen Species
Human
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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