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Xanthurenic Acid

Name: Xanthurenic Acid
Brand: TargetMol
SKU: T3010
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3010Cas No. 59-00-7

Alias xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).

Xanthurenic Acid

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Purity: 99.66%

Catalog No. T3010Alias xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acidCas No. 59-00-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.66%

Appearance:Solid

Resource Download

COA HNMR HPLC

Product Introduction

Xanthurenic Acid AI Summary

Xanthurenic Acid exhibits a diverse range of bioactivities across multiple biological targets. It competitively inhibits the Vesicular glutamate transporter (VGLUT) with a Ki value of 190,000 nM and shows 4.0% inhibitory activity against vesicular glutamate transport (GVT) in synaptic vesicles isolated from rat forebrain. In various inhibitory assays, Xanthurenic Acid demonstrates potencies against several targets: Human Jumonji Domain Containing 2E (JMJD2E) with potencies of 17782.8 nM and 10000.0 nM, Tyrosyl-DNA Phosphodiesterase (TDP1) at 12589.3 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 79432.8 nM, Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia at 9976.3 nM, JMJD2A-Tudor Domain at 28183.8 nM, and HP1-beta Chromodomain Interactions with Methylated Histone Tails at 100000.0 nM. It also inhibits human plasma lipoprotein-associated phospholipase A2 with an IC50 value exceeding 100,000 nM. Moreover, Xanthurenic Acid exhibits a strong inhibitory effect on sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 99.4% and 115.8%, respectively, at an equimolar concentration of 10 µM. It also displays antiallergic activity with an ED50 of 114.0 µmol.kg^-1 and an activity index of 9.1 in Sprague-Dawley rats. Additionally, Xanthurenic Acid shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells, with an IC50 greater than 20000.0 nM at 10 µM concentration after 48 hours exposure to the SARS-CoV-2 virus, suggesting its potential as an antiviral candidate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).
Synonyms	xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

Chemical Properties

Molecular Weight	205.17
Formula	C₁₀H₇NO₄
Cas No.	59-00-7
Smiles	OC(=O)c1cc(O)c2cccc(O)c2n1
Relative Density.	1.569g/cm3

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.06 mg/mL (10.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8740 mL	24.3700 mL	48.7401 mL	243.7003 mL
5 mM	0.9748 mL	4.8740 mL	9.7480 mL	48.7401 mL
10 mM	0.4874 mL	2.4370 mL	4.8740 mL	24.3700 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc