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Rivastigmine

Name: Rivastigmine
Brand: TargetMol
SKU: T0229
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0229Cas No. 123441-03-2

Alias S-Rivastigmine, SDZ-ENA 713, Exelon

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

Rivastigmine

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Purity: 99.45%

Catalog No. T0229Alias S-Rivastigmine, SDZ-ENA 713, ExelonCas No. 123441-03-2

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$47	In Stock	-
50 mg	$55	In Stock	-
100 mg	$81	In Stock	-
200 mg	$108	In Stock	-
500 mg	$135	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.45%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Targets&IC50	ChE:5.5 μM
In vivo	Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Cell Research	Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference)
Synonyms	S-Rivastigmine, SDZ-ENA 713, Exelon

Chemical Properties

Molecular Weight	250.34
Formula	C₁₄H₂₂N₂O₂
Cas No.	123441-03-2
Smiles	CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
Relative Density.	1.038g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (279.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9946 mL	19.9728 mL	39.9457 mL	199.7284 mL
5 mM	0.7989 mL	3.9946 mL	7.9891 mL	39.9457 mL
10 mM	0.3995 mL	1.9973 mL	3.9946 mL	19.9728 mL
20 mM	0.1997 mL	0.9986 mL	1.9973 mL	9.9864 mL
50 mM	0.0799 mL	0.3995 mL	0.7989 mL	3.9946 mL
100 mM	0.0399 mL	0.1997 mL	0.3995 mL	1.9973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc