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Rivastigmine

Name: Rivastigmine
Brand: TargetMol
SKU: T0229
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0229Cas No. 123441-03-2

Alias S-Rivastigmine, SDZ-ENA 713, Exelon

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

Rivastigmine

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Purity: 99.45%

Catalog No. T0229Alias S-Rivastigmine, SDZ-ENA 713, ExelonCas No. 123441-03-2

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$47	In Stock	-
50 mg	$55	In Stock	-
100 mg	$81	In Stock	-
200 mg	$108	In Stock	-
500 mg	$135	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.45%

Appearance:Viscous

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Targets&IC50	ChE:5.5 μM
In vivo	Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Cell Research	Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference)
Synonyms	S-Rivastigmine, SDZ-ENA 713, Exelon

Chemical Properties

Molecular Weight	250.34
Formula	C₁₄H₂₂N₂O₂
Cas No.	123441-03-2
Smiles	CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
Relative Density.	1.038g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (279.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9946 mL	19.9728 mL	39.9457 mL	199.7284 mL
5 mM	0.7989 mL	3.9946 mL	7.9891 mL	39.9457 mL
10 mM	0.3995 mL	1.9973 mL	3.9946 mL	19.9728 mL
20 mM	0.1997 mL	0.9986 mL	1.9973 mL	9.9864 mL
50 mM	0.0799 mL	0.3995 mL	0.7989 mL	3.9946 mL
100 mM	0.0399 mL	0.1997 mL	0.3995 mL	1.9973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc