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(R)-Sulforaphane

Name: (R)-Sulforaphane
Brand: TargetMol
SKU: T8281
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8281Cas No. 142825-10-3

Alias L-Sulforaphane

(R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway.

(R)-Sulforaphane

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Purity: 99.53%

Catalog No. T8281Alias L-SulforaphaneCas No. 142825-10-3

(R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$57	In Stock	In Stock
2 mg	$82	-	In Stock
5 mg	$137	In Stock	In Stock
10 mg	$235	-	In Stock
25 mg	$397	-	In Stock
50 mg	$583	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.53%

Color:Transparent to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

(R)-Sulforaphane AI Summary

(R)-Sulforaphane exhibits multifaceted bioactivities, prominently including the induction of NADPH:quinone reductase (NQO1) activity in various cell lines, indication of potential antioxidant and chemopreventive properties. In mouse Hepa-1c1c7 cells, the effective concentration for doubling NQO1 activity ranges from 0.2 uM to 0.49 uM depending on the assay, suggesting a strong ability to enhance cellular detoxification mechanisms. It also demonstrates cytotoxic effects with IC50 values against different cell lines, such as mouse Hepa-1c1c7 cells at 11,000 nM to 27,300 nM, indicating variance in sensitivity. Moreover, (R)-Sulforaphane shows inhibitory activities against Trypanosoma cruzi (with IC50 values ranging from 15,000 to 120,000 nM) and has significant antiproliferative effects against multiple human cancer cell lines, including A549, A375, HCT116, and HeLa cells with IC50 values ranging from 6308 to 25130 nM. Additionally, it modulates Nrf2-mediated pathways, inducing gene expression changes related to oxidative stress response via the Keap1/Nrf2/ARE pathway, with EC50 values as low as 580 nM in some assays. The compound also demonstrates antileishmanial activity against Leishmania donovani and Leishmania infantum with IC50 values of 16500 nM and 23300 nM, respectively, and significant induction of apoptosis in various cell types. Its ability to inhibit macrophage migration inhibitory factor (MIF) tautomerase activity, as well as effects on cytokine-cytokine receptor interaction and other gene expression pathways, further suggest its broad spectrum of potential therapeutic applications. In terms of pharmacokinetics, (R)-Sulforaphane has shown rapid metabolism and clearance with short half-lives in both rat and human models. Finally, it displays protective effects in specific contexts, such as renoprotective activity against cisplatin-induced cytotoxicity in pig LLC-PK1 cells and cytoprotection in oxidative stress models. These diverse bioactivities underscore its potential as a versatile agent in both therapeutic and research contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway.
Synonyms	L-Sulforaphane

Chemical Properties

Molecular Weight	177.29
Formula	C₆H₁₁NOS₂
Cas No.	142825-10-3
Smiles	C(CCN=C=S)CS(C)=O
Relative Density.	1.17 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (90.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6405 mL	28.2024 mL	56.4048 mL	282.0238 mL
5 mM	1.1281 mL	5.6405 mL	11.2810 mL	56.4048 mL
10 mM	0.5640 mL	2.8202 mL	5.6405 mL	28.2024 mL
20 mM	0.2820 mL	1.4101 mL	2.8202 mL	14.1012 mL
50 mM	0.1128 mL	0.5640 mL	1.1281 mL	5.6405 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc