HIV-1 inhibitor-66

Name: HIV-1 inhibitor-66
Brand: TargetMol
SKU: T209629
Rating: 4.5 (1 reviews)

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Catalog No. T209629

HIV-1inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits inhibitory activity against wild-type HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) with an IC50 of 40 nM.

HIV-1 inhibitor-66

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Catalog No. T209629

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Product Introduction

Bioactivity

Description	HIV-1inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits inhibitory activity against wild-type HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) with an IC50 of 40 nM.
In vitro	HIV-1 inhibitor-66 (compound 10n) effectively inhibits wild-type (WT) HIV-1 (IIIB) and NNRTI-resistant strains. The EC 50 values for HIV-1 IIIB, L100I, K103N, Y181C, Y188L, E138K, F227L/V106A, and RES056 (K103N/Y181C) are 0.009 μM, 0.011 μM, 0.013 μM, 0.018 μM, 0.703 μM, 0.013 μM, 17.7 μM, and 0.059 μM, respectively.
In vivo	HIV-1 inhibitor-66 (compound 10n) exhibits excellent pharmacokinetic properties in rats, characterized by a half-life (T 1/2) of 5.09 hours and a bioavailability (F) of 108.96%. It has been verified to have no acute or subacute toxicity in vivo, with an LD50 greater than 2000 mg/kg.

Chemical Properties

Formula

C₂₂H₁₅BrClF₃N₄O₃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc