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1-Methyl-1,2,3,4-tetrahydroisoquinoline

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Catalog No. TN9617Cas No. 4965-09-7

1-Methyl-1,2,3,4-tetrahydroisoquinoline is an inhibitor of phenylethanolamine N-methyltransferase and can be used in biochemical experiments and drug synthesis.

1-Methyl-1,2,3,4-tetrahydroisoquinoline

1-Methyl-1,2,3,4-tetrahydroisoquinoline

🥰Excellent
Catalog No. TN9617Cas No. 4965-09-7
1-Methyl-1,2,3,4-tetrahydroisoquinoline is an inhibitor of phenylethanolamine N-methyltransferase and can be used in biochemical experiments and drug synthesis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$35-In Stock
1 g$50-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
1-Methyl-1,2,3,4-tetrahydroisoquinoline is an inhibitor of phenylethanolamine N-methyltransferase and can be used in biochemical experiments and drug synthesis.
In vivo
Methods: STZ-induced diabetic mice were treated with 1-Methyl-1,2,3,4-tetrahydroisoquinoline (15, 30, 45 mg/kg, intraperitoneal injection) to study its effects on STZ-induced diabetic static mechanical allodynia.
Results: The highest dose of 1-Methyl-1,2,3,4-tetrahydroisoquinoline (45 mg/kg) induced a more significant reversal of DPN allodynia 30 minutes after administration. [1]
Chemical Properties
Molecular Weight147.22
FormulaC10H13N
Cas No.4965-09-7
SmilesC=1C=CC2=C(C1)CCNC2C
Storage & Solubility Information
Storagestore under nitrogen,keep away from direct sunlight | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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