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NPC2 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-01114

NPC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.67 kDa and the accession number is P61916-1.

NPC2 Protein, Human, Recombinant (His)

NPC2 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-01114
NPC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.67 kDa and the accession number is P61916-1.
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100 μg$7007-10 days
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Product Information

Biological Activity
Activity testing is not tested. It is theoretically active, but we cannot guarantee it.
Description
NPC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.67 kDa and the accession number is P61916-1.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberP61916-1
Synonyms
Niemann-Pick disease, type C2,HE1,EDDM1
Construction
Glu20-Leu151
Protein Purity
> 95% as determined by Tris-Bis PAGE
Molecular Weight15.67 kDa (Predicted); 21-24 kDa and 27-35 kDa (Due to glycosylation)
EndotoxinLess than 1EU per μg by the LAL method.
FormulationLyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
The Niemann Pick type C (NPC) proteins, NPC1 and NPC2, are involved in the lysosomal storage disease, NPC disease. The formation of a NPC1⁻NPC2 protein⁻protein complex is believed to be necessary for the transfer of cholesterol and lipids out of the late endosomal (LE)/lysosomal (Lys) compartments. Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease.

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