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Bitoscanate

Name: Bitoscanate
Brand: TargetMol
SKU: T1383
Rating: 4.5 (1 reviews)

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Catalog No. T1383Cas No. 4044-65-9

Alias p-Phenylene diisothiocyanate, PDITC, Biscomate, 1,4-Diisothiocyanatobenzene

Bitoscanate (PDITC) is used in the treatment of hookworms.

Bitoscanate

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Catalog No. T1383Alias p-Phenylene diisothiocyanate, PDITC, Biscomate, 1,4-DiisothiocyanatobenzeneCas No. 4044-65-9

Bitoscanate (PDITC) is used in the treatment of hookworms.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$29	Inquiry	Inquiry
200 mg	$39	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bitoscanate AI Summary

Bitoscanate exhibits a range of bioactivities across different assays. In a VEGF-stimulated ADSC/ECFC co-culture, it reduces both nuclear area (viability) and CD31-stained tube area with an IC50 of 10000.0 nM. It demonstrates antiproliferative activity against human LoVo cells and LoVo/DX cells, with IC50 values of 9410.0 nM and 11600.0 nM respectively, after 72 hours. Additionally, it shows antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, observed as a -1.4% inhibition rate, and in VERO-6 cells with a 0.07% inhibition rate. Bitoscanate also inhibits the SARS-CoV-2 3CL-Pro protease at 20 µM, with an inhibition rate of 9.529%. Furthermore, it displays inhibitory activity against the human HDAC6 enzyme, showing 15.83% inhibition in an assay with a commercial peptide substrate and 10.01% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bitoscanate (PDITC) is used in the treatment of hookworms.
Synonyms	p-Phenylene diisothiocyanate, PDITC, Biscomate, 1,4-Diisothiocyanatobenzene

Chemical Properties

Molecular Weight	192.26
Formula	C₈H₄N₂S₂
Cas No.	4044-65-9
Smiles	S=C=NC1=CC=C(C=C1)N=C=S
Relative Density.	1.2g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 20 mg/mL (104.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (10.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2013 mL	26.0064 mL	52.0129 mL	260.0645 mL
5 mM	1.0403 mL	5.2013 mL	10.4026 mL	52.0129 mL
10 mM	0.5201 mL	2.6006 mL	5.2013 mL	26.0064 mL
20 mM	0.2601 mL	1.3003 mL	2.6006 mL	13.0032 mL
50 mM	0.1040 mL	0.5201 mL	1.0403 mL	5.2013 mL
100 mM	0.0520 mL	0.2601 mL	0.5201 mL	2.6006 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc