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Nisoxetine

Name: Nisoxetine
Brand: TargetMol
SKU: T69145
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69145Cas No. 53179-07-0

Nisoxetine is a selective NET (noradrenaline transporter) inhibitor (Kd=0.76 nM) capable of blocking voltage-gated sodium channels, inducing spinal anaesthesia in rats, and exhibiting antidepressant effects.

Nisoxetine

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Purity: 98.71%

Catalog No. T69145Cas No. 53179-07-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$123	-	In Stock
25 mg	$247	-	In Stock
50 mg	$396	-	In Stock
100 mg	$648	-	In Stock
200 mg	$892	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.71%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nisoxetine is a selective NET (noradrenaline transporter) inhibitor (Kd=0.76 nM) capable of blocking voltage-gated sodium channels, inducing spinal anaesthesia in rats, and exhibiting antidepressant effects.
Targets&IC50	NET:0.76 nM (Kd)
In vitro	Nisoxetine inhibits the binding of [3H]Nisoxetine on rat frontal cortex membranes with a Ki = 1.4 ± 0.1 nM[2]. Nisoxetine inhibits the uptake of [3H]norepinephrine in rat frontal cortex synaptosomes with a Ki = 2.1 ± 0.3 nM[2]. At membrane potentials of -70 mV and -100 mV, the IC50 values of Nisoxetine for Na+ currents are 1.6 μM and 28.6 μM, respectively[3].
In vivo	Acute administration of Nisoxetine (saline: 0, 3, 10, and 30 mg/kg; i.p.) resulted in a dose-dependent reduction in the 24 h refeeding response in male Sprague Dawley rats maintained on standard chow [4].

Chemical Properties

Molecular Weight	271.35
Formula	C₁₇H₂₁NO₂
Cas No.	53179-07-0
Color	Brown
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (737.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6853 mL	18.4264 mL	36.8528 mL	184.2639 mL
5 mM	0.7371 mL	3.6853 mL	7.3706 mL	36.8528 mL
10 mM	0.3685 mL	1.8426 mL	3.6853 mL	18.4264 mL
20 mM	0.1843 mL	0.9213 mL	1.8426 mL	9.2132 mL
50 mM	0.0737 mL	0.3685 mL	0.7371 mL	3.6853 mL
100 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc