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Nisoxetine

Name: Nisoxetine
Brand: TargetMol
SKU: T69145
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69145Cas No. 53179-07-0

Nisoxetine is a selective NET (noradrenaline transporter) inhibitor (Kd=0.76 nM) capable of blocking voltage-gated sodium channels, inducing spinal anaesthesia in rats, and exhibiting antidepressant effects.

Nisoxetine

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Purity: 98.71%

Catalog No. T69145Cas No. 53179-07-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$123	-	In Stock
25 mg	$247	-	In Stock
50 mg	$396	-	In Stock
100 mg	$648	-	In Stock
200 mg	$892	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.71%

Appearance:Oil

Color:Brown

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nisoxetine is a selective NET (noradrenaline transporter) inhibitor (Kd=0.76 nM) capable of blocking voltage-gated sodium channels, inducing spinal anaesthesia in rats, and exhibiting antidepressant effects.
Targets&IC50	NET:0.76 nM (Kd)
In vitro	Nisoxetine inhibits the binding of [3H]Nisoxetine on rat frontal cortex membranes with a Ki = 1.4 ± 0.1 nM[2]. Nisoxetine inhibits the uptake of [3H]norepinephrine in rat frontal cortex synaptosomes with a Ki = 2.1 ± 0.3 nM[2]. At membrane potentials of -70 mV and -100 mV, the IC50 values of Nisoxetine for Na+ currents are 1.6 μM and 28.6 μM, respectively[3].
In vivo	Acute administration of Nisoxetine (saline: 0, 3, 10, and 30 mg/kg; i.p.) resulted in a dose-dependent reduction in the 24 h refeeding response in male Sprague Dawley rats maintained on standard chow [4].

Chemical Properties

Molecular Weight	271.35
Formula	C₁₇H₂₁NO₂
Cas No.	53179-07-0
Smiles	O(C=1C=CC=CC1OC(C=2C=CC=CC2)CCNC)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (737.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6853 mL	18.4264 mL	36.8528 mL	184.2639 mL
5 mM	0.7371 mL	3.6853 mL	7.3706 mL	36.8528 mL
10 mM	0.3685 mL	1.8426 mL	3.6853 mL	18.4264 mL
20 mM	0.1843 mL	0.9213 mL	1.8426 mL	9.2132 mL
50 mM	0.0737 mL	0.3685 mL	0.7371 mL	3.6853 mL
100 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc